Formulations:

• Cefaclor Dispersible Tablets (DS):

• • • Strengths: 125mg DS, 250mg DS
    • Product Form: Dispersible tablets for oral administration
    • Packing Specs: Available in blister packs of 60ml tablets

• Cefaclor Capsules:

• • Strengths: 250mg, 500mg
  • Product Form: Hard gelatin capsules for oral administration
  • Packing Specs: Available in blister packs of 12’s

Indications:

Cefaclor is indicated for the treatment of various bacterial infections caused by susceptible organisms, including:

• Upper respiratory tract infections, such as otitis media, sinusitis, and pharyngitis
• Lower respiratory tract infections, including bronchitis and pneumonia
• Urinary tract infections, such as cystitis and pyelonephritis
• Skin and soft tissue infections, including cellulitis and impetigo
• Genitourinary tract infections, including gonorrhea caused by penicillinase-producing strains of Neisseria gonorrhoeae

Pharmacokinetics:

• Absorption: Cefaclor is well absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours.
• Distribution: The drug distributes widely into various body tissues and fluids, achieving therapeutic concentrations in the respiratory tract, urinary tract, and skin.
• Metabolism: Cefaclor undergoes minimal metabolism in the body, with approximately 15-40% excreted unchanged in the urine.
• Elimination: The elimination half-life of cefaclor is approximately 0.6-0.9 hours in adults with normal renal function.

Pharmacodynamics:

• Cefaclor exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell death.

Usage:

• Cefaclor tablets and capsules should be taken orally with or without food.
• Dispersible tablets should be dissolved in water to form a suspension for administration, especially in pediatric patients.

Dosage:

• The dosage of Cefaclor varies depending on the type and severity of the infection, as well as the patient’s age and weight.
• The usual adult dosage for most infections is 250mg to 500mg every 8 hours.
• Pediatric dosages are determined based on the child’s weight and the severity of the infection.

Side Effects:

• Common side effects of Cefaclor may include:

• • • Gastrointestinal disturbances, such as nausea, vomiting, diarrhea, and abdominal pain
    • Skin rash, itching, and urticaria
    • Headache, dizziness, and fatigue

• Serious side effects such as pseudomembranous colitis and anaphylaxis are rare but may occur.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Cefaclor Range in the treatment of bacterial infections. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.