Pharmacokinetics:

• Absorption: Cefixime is well absorbed after oral administration, with peak plasma concentrations achieved within 2-6 hours.
• Distribution: The drug distributes widely into various body tissues and fluids, achieving therapeutic concentrations in the respiratory tract, urinary tract, and skin.
• Metabolism: Cefixime undergoes minimal metabolism in the body, with approximately 50% of the drug excreted unchanged in the urine.
• Elimination: The elimination half-life of cefixime is approximately 3-4 hours in adults with normal renal function.

Pharmacodynamics:

• Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell death.

Formulations:

• Cefixime Dispersible Tablets (DS):

• • • Strengths: 100mg DS, 200mg DS
    • Product Form: Dispersible tablets for oral administration
    • Packing Specs: Available in blister packs of 30ml tablets

• Cefixime Capsules:

• • Strength: 400mg
  • Product Form: Hard gelatin capsules for oral administration
  • Packing Specs: Available in blister packs of 5’s

Indications:

Cefixime is indicated for the treatment of various bacterial infections caused by susceptible organisms, including:

• Upper respiratory tract infections, such as pharyngitis, tonsillitis, and sinusitis
• Lower respiratory tract infections, including bronchitis and community-acquired pneumonia
• Urinary tract infections, such as cystitis and pyelonephritis
• Uncomplicated gonorrhea caused by Neisseria gonorrhoeae
• Uncomplicated infections of the skin and soft tissues

Usage:

• Cefixime tablets and capsules are intended for oral administration and should be taken with or without food.
• The tablets can be dissolved in water to form a suspension for easier administration, especially in pediatric patients.

Dosage:

• The dosage of Cefixime varies depending on the type and severity of the infection, as well as the patient’s age and weight.
• The usual adult dosage for most infections is 400mg once daily or divided into two doses of 200mg twice daily.
• Pediatric dosages are determined based on the child’s weight and the severity of the infection.

Side Effects:

• Common side effects of Cefixime may include:
  • Gastrointestinal disturbances, such as nausea, vomiting, diarrhea, and abdominal pain
  • Headache, dizziness, and fatigue
  • Allergic reactions, including rash and itching
• Serious side effects such as pseudomembranous colitis and anaphylaxis are rare but may occur.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Cefixime Range in the treatment of bacterial infections. For more information, please contact us.