Description

Formulations:

• Cefazolin Vials:
  • Strengths: 250mg and 500mg
  • Product Form: Lyophilized powder for reconstitution for intravenous or intramuscular administration
  • Packing Specs: Available in vial packs of 1’s

Indications:

Cefazolin is indicated for the treatment of various bacterial infections caused by susceptible organisms, including:

• Skin and soft tissue infections, such as cellulitis and wound infections
• Surgical prophylaxis, including preoperative and postoperative prophylaxis to reduce the risk of surgical site infections
• Respiratory tract infections, such as pneumonia and bronchitis
• Urinary tract infections, including cystitis and pyelonephritis
• Bone and joint infections
• Endocarditis prophylaxis in patients undergoing certain surgical or dental procedures

Pharmacokinetics:

• Absorption: Cefazolin is not absorbed orally and must be administered via intravenous or intramuscular routes.
• Distribution: The drug distributes widely into various body tissues and fluids, achieving therapeutic concentrations in the skin, bone, and respiratory tract.
• Metabolism: Cefazolin undergoes minimal metabolism in the body, with the majority of the drug excreted unchanged in the urine.
• Elimination: The elimination half-life of cefazolin is approximately 1.5-2 hours in adults with normal renal function.

Pharmacodynamics:

• Cefazolin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell death.

Usage:

• Cefazolin vials are intended for intravenous or intramuscular administration after reconstitution with a suitable diluent.
• Healthcare professionals should follow the recommended dilution and infusion rates provided in the prescribing information.

Dosage:

• The dosage of Cefazolin varies depending on the type and severity of the infection, as well as the patient’s age, weight, and renal function.
• Dosage adjustments may be necessary in patients with impaired renal function to prevent drug accumulation and toxicity.

Side Effects:

• Common side effects of Cefazolin may include:
  • Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea
  • Skin rash and allergic reactions
  • Superinfections, including fungal infections
• Serious side effects such as anaphylaxis and pseudomembranous colitis may occur, although they are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Cefazolin Range in the management of bacterial infections. For more information, please contact us.