Formulations:

• Flurbiprofen BP Tablets:
  • Strength: Available in 50mg and 100mg formulations
  • Product Form: Oral tablets for easy administration
  • Packing Specifications: Each pack contains 30 tablets for your convenience

Indications:

Flurbiprofen BP is indicated for the treatment of various inflammatory and painful conditions, including:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute gout
• Musculoskeletal disorders
• Dental pain
• Primary dysmenorrhea

Usage:

• Flurbiprofen tablets are intended for oral administration.
• The dosage and duration of treatment should be individualized based on the severity of the condition and the patient’s response to therapy.
• It is recommended to take Flurbiprofen with food or milk to minimize gastrointestinal side effects.

Dosage:

• The recommended dosage of Flurbiprofen typically ranges from 100mg to 300mg per day, divided into two to four doses.
• For mild to moderate pain or inflammation, a starting dose of 50mg to 100mg every 4 to 6 hours may be sufficient.
• Dosage adjustments may be necessary in elderly patients, patients with renal or hepatic impairment, and those at risk of gastrointestinal adverse effects.

Pharmacokinetics:

• Absorption: Flurbiprofen is rapidly absorbed following oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• Distribution: Flurbiprofen is highly protein-bound and widely distributed throughout the body, including synovial fluid.
• Metabolism: Flurbiprofen undergoes extensive hepatic metabolism, primarily via hydroxylation and conjugation, leading to the formation of inactive metabolites.
• Elimination: The elimination half-life of Flurbiprofen is approximately 3 to 6 hours, with the majority of the drug excreted renally as metabolites.

Pharmacodynamics:

• Flurbiprofen exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins involved in the inflammatory process.

Side Effects:

• Common side effects of Flurbiprofen may include:
  • Gastrointestinal disturbances such as dyspepsia, abdominal pain, and gastritis
  • Renal impairment, including fluid retention and edema
  • Hematological effects such as anemia and thrombocytopenia
  • Skin reactions, including rash and photosensitivity
• Serious adverse reactions such as gastrointestinal bleeding, renal failure, and hypersensitivity reactions may occur, particularly with prolonged use or in patients with pre-existing conditions.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Flurbiprofen Range for effective pain relief and inflammation management. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.