Description

Formulations:

• Diclofenac Tablets:
  • Strength: Available in 50mg and 100mg formulations
  • Product Form: Oral tablets for convenient administration
  • Packing Specifications: Each pack contains 20 tablets for your convenience
• Diclofenac Liquid Ampules:
  • Strength: Available in 75 mg formulations
  • Product Form: Liquid ampules for parenteral administration
  • Packing Specifications: Each pack contains 5 ampules for ease of use

Indications:

Diclofenac is indicated for the treatment of various painful and inflammatory conditions, including:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute gout
• Musculoskeletal disorders
• Postoperative pain
• Dysmenorrhea
• Migraine headaches

Usage:

• Diclofenac tablets are intended for oral administration.
• Diclofenac liquid ampules are suitable for parenteral administration via intramuscular or intravenous injection.
• The dosage and duration of treatment should be individualized based on the severity of the condition and the patient’s response to therapy.
• Diclofenac tablets should be taken with food or milk to minimize gastrointestinal side effects.

Dosage:

• The recommended dosage of Diclofenac varies depending on the indication and the patient’s response to treatment.
• For mild to moderate pain or inflammation, a starting dose of 50mg to 75mg twice daily may be sufficient.
• Dosage adjustments may be necessary in elderly patients, patients with renal or hepatic impairment, and those at risk of gastrointestinal adverse effects.

Pharmacokinetics:

• Absorption: Diclofenac is rapidly and almost completely absorbed following oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• Distribution: Diclofenac is extensively bound to plasma proteins and has a large volume of distribution.
• Metabolism: Diclofenac undergoes hepatic metabolism, primarily via cytochrome P450 enzymes, leading to the formation of several metabolites.
• Elimination: The elimination half-life of Diclofenac is approximately 1 to 2 hours. The drug and its metabolites are excreted primarily in the urine, with a small portion excreted in the feces.

Pharmacodynamics:

• Diclofenac exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins involved in the inflammatory process.

Side Effects:

• Common side effects of Diclofenac may include:
  • Gastrointestinal disturbances such as dyspepsia, abdominal pain, and gastritis
  • Renal impairment, including fluid retention and edema
  • Hematological effects such as anemia and thrombocytopenia
  • Skin reactions, including rash and photosensitivity
• Serious adverse reactions such as gastrointestinal bleeding, renal failure, and hypersensitivity reactions may occur, particularly with prolonged use or in patients with pre-existing conditions.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Diclofenac Range for effective pain relief and inflammation management. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.