Drug Classification:

Thiocolchicoside belongs to the class of medications known as muscle relaxants. It works by acting directly on the central nervous system to reduce muscle tone and relieve muscle spasms.

Formulations:

• Thiocolchicoside Tablets:
  • Strength: Available in 4mg tablets
  • Product Form: Oral tablets for convenient administration
  • Packing Specifications: Each pack contains 20 tablets for extended use
• Thiocolchicoside Liquid Ampuls:
  • Strength: Available in 4 mg liquid ampuls
  • Product Form: Injectable solution for rapid onset of action
  • Packing Specifications: Each pack contains 5 ampuls for easy dosing

Indications:

Thiocolchicoside is indicated for the treatment of:

• Acute and chronic muscle spasms
• Musculoskeletal conditions such as back pain, neck pain, and sciatica
• Muscle stiffness and rigidity associated with neurological disorders

Usage:

• Thiocolchicoside tablets should be taken orally with water, preferably after meals, to minimize gastrointestinal discomfort.
• The liquid ampuls are administered via intramuscular injection by a qualified healthcare professional for rapid relief of muscle spasms.
• It is essential to follow the prescribed dosage and duration of treatment as directed by your healthcare provider.

Dosage:

• The recommended dosage of Thiocolchicoside may vary depending on the severity of the muscle spasm and individual patient response.
• For oral tablets, the usual starting dose is 4 mg taken two to three times daily. Dosage adjustments may be made based on the patient’s response and tolerability.
• For intramuscular injection, the recommended dose is usually 4 mg administered once or twice daily, as needed for acute relief of muscle spasms.

Pharmacokinetics:

• Absorption: Thiocolchicoside is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• Distribution: The drug is extensively distributed throughout the body, including to skeletal muscles, where it exerts its muscle relaxant effects.
• Metabolism: Thiocolchicoside undergoes hepatic metabolism, primarily via glucuronidation, and is excreted in the urine as metabolites.
• Elimination: The elimination half-life of Thiocolchicoside is approximately 2 to 3 hours, with the majority of the drug and its metabolites excreted in the urine.

Pharmacodynamics:

• Thiocolchicoside acts centrally on the spinal cord and brainstem to inhibit the transmission of pain signals and reduce muscle hyperexcitability, leading to muscle relaxation and pain relief.

Side Effects:

• Common side effects of Thiocolchicoside may include:
  • Drowsiness, dizziness, and fatigue
  • Gastrointestinal upset, including nausea and vomiting
  • Headache, dry mouth, and blurred vision
• Serious adverse reactions such as allergic reactions and hepatotoxicity are rare but may occur in some individuals.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Thiocolchicoside Range for the management of muscle spasms. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.