Description

Drug Classification:

Mebeverine belongs to the class of medications known as antispasmodics. It acts directly on the smooth muscles of the gastrointestinal tract, relieving spasms and associated symptoms.

Formulations:

• Mebeverine Tablets:
  • Strength: Available in 135mg and 200mg tablets
  • Product Form: Oral tablets for convenient administration
  • Packing Specifications: 135mg tablets are packed in containers of 30 tablets, while 200mg tablets are packed in containers of 10 tablets.

Indications:

Mebeverine is indicated for the treatment of:

• Irritable bowel syndrome (IBS)
• Functional gastrointestinal disorders characterized by abdominal pain, bloating, and altered bowel habits
• Spastic colitis
• Mucous colitis

Usage:

• Mebeverine tablets should be taken orally with water, preferably before meals to maximize absorption.
• The medication should be used as directed by a healthcare professional to achieve optimal results.
• It is essential to continue taking Mebeverine regularly as prescribed, even if symptoms improve, to maintain symptom relief.

Dosage:

• The recommended dosage of Mebeverine may vary depending on the severity of symptoms and individual patient response.
• For adults and children over 10 years of age, the usual starting dose is one 135mg tablet taken three times daily. Dosage adjustments may be made based on the patient’s response and tolerability.
• The 200mg tablets may be prescribed for patients requiring higher doses, with one tablet taken three times daily.

Pharmacokinetics:

• Absorption: Mebeverine is well absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations reached within 1 to 2 hours.
• Distribution: The drug is widely distributed throughout the body, including to the smooth muscles of the gastrointestinal tract.
• Metabolism: Mebeverine undergoes extensive first-pass metabolism in the liver, primarily via hydrolysis to inactive metabolites.
• Elimination: The elimination half-life of Mebeverine is approximately 2 to 3 hours, and the majority of the drug and its metabolites are excreted in the urine.

Pharmacodynamics:

• Mebeverine acts locally on the smooth muscles of the gastrointestinal tract, inhibiting muscle contractions and reducing spasms. This action helps alleviate symptoms such as abdominal pain, cramping, and bloating associated with gastrointestinal disorders.

Side Effects:

• Common side effects of Mebeverine may include:
  • Nausea, vomiting, and gastrointestinal upset
  • Headache, dizziness, and fatigue
  • Allergic reactions such as rash or itching
• Serious adverse reactions are rare but may include severe allergic reactions or anaphylaxis.

Experience the relief provided by AIT Pharmaceuticals Division’s Mebeverine Range for gastrointestinal disorders. For more information, please contact us. We are committed to providing effective and reliable pharmaceutical solutions to healthcare professionals worldwide.