Drug Classification:

Artemether is classified as an antimalarial agent. It belongs to the artemisinin class of drugs, which are derived from the sweet wormwood plant (Artemisia annua). Artemisinin-based combination therapies (ACTs) are recommended by the World Health Organization (WHO) as first-line treatments for uncomplicated and severe malaria.

Formulation:

• Artemether Injection:
  • Strength: Each vial contains 80mg of Artemether.
  • Product Form: Sterile solution for intramuscular or intravenous administration.
  • Packing Specifications: Packaged in vials, with each pack containing 6 vials.

Indications:

Artemether Injection is indicated for the treatment of severe malaria caused by Plasmodium falciparum, particularly in cases where resistance to other antimalarial drugs is suspected or confirmed. It is not recommended for the treatment of uncomplicated malaria.

Usage:

• Artemether Injection should only be administered under the supervision of a qualified healthcare professional experienced in the management of severe malaria.
• The route of administration (intramuscular or intravenous) and dosage regimen should be determined based on the severity of the patient’s condition, their age, weight, and other clinical factors.

Dosage:

• The recommended dosage of Artemether Injection for the treatment of severe malaria varies based on factors such as the patient’s age, weight, and the severity of the infection.
• Dosage regimens typically involve initial loading doses followed by maintenance doses administered at specified intervals.
• Healthcare providers should adhere to established treatment guidelines and adjust the dosage as necessary based on the patient’s response to therapy.

Pharmacokinetics:

• Artemether is rapidly absorbed following intramuscular or intravenous administration and undergoes extensive metabolism in the liver to its active metabolite dihydroartemisinin.
• Dihydroartemisinin exerts potent antimalarial activity, rapidly killing malaria parasites and reducing parasitemia levels.

Pharmacodynamics:

• Artemether acts rapidly to kill malaria parasites, particularly the early stages of the parasite’s life cycle, including the ring and trophozoite stages.
• By rapidly reducing parasite burden, Artemether Injection helps alleviate symptoms of severe malaria and prevents progression to life-threatening complications.

Side Effects:

• Common side effects associated with Artemether Injection may include gastrointestinal disturbances (nausea, vomiting, diarrhea), dizziness, headache, and injection site reactions.
• Rare but serious adverse effects such as cardiotoxicity, neurotoxicity, and allergic reactions may occur and should be promptly reported to healthcare providers.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Artemether Injection in the treatment of severe malaria. For more information, please contact us. We are committed to advancing global health through innovative pharmaceutical solutions.