Drug Classification:

Hydroxychloroquine sulfate belongs to the class of medications known as antimalarials and disease-modifying antirheumatic drugs (DMARDs). It is commonly used to treat malaria, rheumatoid arthritis, and systemic lupus erythematosus (SLE).

Formulations:

• Hydroxychloroquine Sulfate Tablets:
  • Strength: Each tablet contains 200 mg of hydroxychloroquine sulfate.
  • Product Form: Oral tablets for easy administration.
  • Packing Specifications: Packaged in blister packs containing 30 tablets for convenient dosing.

Indications:

Hydroxychloroquine Sulfate Tablets are indicated for the following conditions:

• Malaria: Treatment and prophylaxis of malaria caused by Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum.
• Rheumatoid Arthritis: Management of rheumatoid arthritis, including acute and chronic cases.
• Systemic Lupus Erythematosus (SLE): Treatment of acute and chronic forms of SLE and discoid lupus erythematosus.

Usage:

• Hydroxychloroquine Sulfate Tablets should be taken orally with food or milk to reduce gastrointestinal discomfort.
• It is important to adhere to the prescribed dosage and duration of treatment as directed by your healthcare provider.
• Do not crush or chew the tablets; swallow them whole with a full glass of water.

Dosage:

• The dosage of Hydroxychloroquine Sulfate varies depending on the condition being treated.
• For malaria prophylaxis, the usual adult dose is 400 mg once weekly, starting 2 weeks before exposure and continuing for 4 to 8 weeks after leaving the malaria-endemic area.
• For rheumatoid arthritis and systemic lupus erythematosus, the recommended initial dose is usually 400 to 600 mg daily, with maintenance doses ranging from 200 to 400 mg daily.

Pharmacokinetics:

• Hydroxychloroquine is well absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 3 to 6 hours after oral administration.
• It has a large volume of distribution and is extensively distributed into tissues, including the liver, spleen, kidney, and lung.
• Hydroxychloroquine is metabolized mainly in the liver, and its elimination half-life ranges from 40 to 50 days.

Pharmacodynamics:

• The exact mechanism of action of hydroxychloroquine in the treatment of malaria and autoimmune diseases is not fully understood.
• However, it is believed to exert its therapeutic effects by interfering with various cellular processes, including lysosomal function, antigen presentation, and cytokine production.

Side Effects:

• Common side effects of Hydroxychloroquine Sulfate Tablets may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal cramps.
• Other potential side effects include headache, dizziness, skin rashes, and changes in vision.
• Serious adverse effects, although rare, may include retinopathy, cardiomyopathy, and hematological disorders.
• It is essential to report any unusual symptoms or adverse reactions to your healthcare provider promptly.

Trust in the efficacy and safety of Hydroxychloroquine Sulfate Tablets from AIT Pharmaceuticals Division. We are dedicated to meeting the healthcare needs of our patients and ensuring their well-being. For more information, please visit our website or consult your healthcare provider.