Description

Drug Classification:

Duloxetine Capsules belong to the class of drugs known as serotonin-norepinephrine reuptake inhibitors (SNRIs). This medication works by increasing the levels of serotonin and norepinephrine in the brain, which helps regulate mood, reduce pain signals, and improve overall mental health.

Formulations:

• Duloxetine Capsules:
  • Strength: Available in 30 mg and 60 mg strengths.
  • Product Form: Oral capsules for easy administration.
  • Packing Specs: Each pack contains 10 capsules.

Indications:

Duloxetine Capsules are indicated for the treatment of the following conditions:

• Major Depressive Disorder (MDD): Duloxetine is effective in relieving symptoms associated with major depression, including persistent sadness, loss of interest or pleasure in activities, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness or guilt, and difficulty concentrating.
• Generalized Anxiety Disorder (GAD): This medication is also indicated for the management of generalized anxiety disorder, helping to reduce excessive worry and tension.
• Neuropathic Pain: Duloxetine is approved for the treatment of chronic pain conditions such as diabetic neuropathy, fibromyalgia, and chronic musculoskeletal pain.

Usage:

• Duloxetine Capsules should be taken orally with water, with or without food.
• It is important to follow the prescribed dosage and dosing schedule as directed by a healthcare professional.
• Capsules should be swallowed whole and not crushed, chewed, or opened, as this may affect the release of the medication.

Dosage:

• The recommended starting dose of Duloxetine for most adults is 30 mg once daily.
• Dosage adjustments may be made based on individual response and tolerability, with a maximum recommended dose of 60 mg once daily.
• Dosage adjustments may also be necessary in patients with hepatic impairment or renal impairment.

Pharmacokinetics:

• Duloxetine is rapidly absorbed after oral administration, with peak plasma concentrations reached within 6 hours.
• It undergoes extensive hepatic metabolism via the CYP1A2 and CYP2D6 enzymes, forming inactive metabolites that are primarily excreted in the urine.
• The elimination half-life of duloxetine ranges from 8 to 17 hours, allowing for once-daily dosing in most patients.

Pharmacodynamics:

• Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system, thereby increasing the concentration of these neurotransmitters in the synaptic cleft.
• This dual mechanism of action enhances neurotransmission and modulates mood, reducing symptoms of depression and anxiety while also providing analgesic effects in chronic pain conditions.

Side Effects:

• Common side effects associated with Duloxetine Capsules may include nausea, dry mouth, constipation, dizziness, fatigue, insomnia, and sweating.
• Less common but potentially serious side effects may include serotonin syndrome, hyponatremia, suicidal ideation, liver injury, and bleeding events.
• Patients should be advised to report any new or worsening symptoms to their healthcare provider promptly.

Trust in the efficacy and safety of Duloxetine Capsules from AIT Pharmaceuticals Division. Whether you are managing depression, anxiety, or chronic pain, our product offers a reliable solution to help you achieve symptom relief and improve your quality of life. For more information, please visit our website or consult your healthcare provider.