Drug Classification:

Buspirone hydrochloride belongs to the class of drugs known as azapirone anxiolytics. It exerts its therapeutic effects by selectively binding to serotonin (5-HT1A) receptors in the brain, modulating neurotransmitter activity, and alleviating symptoms of anxiety without causing sedation or dependence.

Formulations:

• Buspirone Hydrochloride Tablets:
  • Strengths: Available in 5mg and 10mg tablets.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 30 tablets.

Indications:

Buspirone Hydrochloride Tablets are indicated for the management of:

• Generalized Anxiety Disorder (GAD): Buspirone effectively reduces excessive worry, tension, and other symptoms associated with GAD.
• Relief of Acute Anxiety Symptoms: Buspirone can provide symptomatic relief from acute episodes of anxiety or situational stress.

Usage:

• Buspirone Hydrochloride Tablets should be taken orally, with or without food, as directed by a healthcare professional.
• The dosage regimen may vary depending on the severity of symptoms and individual response to treatment.
• It is essential to follow the prescribed dosage and administration instructions for optimal therapeutic benefits.

Dosage:

• The recommended starting dose of Buspirone for adults is typically 5mg to 10mg taken two to three times daily.
• Dosage adjustments may be made based on the individual’s response to treatment and tolerability, with a maximum daily dose of 60mg.
• Elderly patients and individuals with hepatic or renal impairment may require lower initial doses and careful dose titration under medical supervision.

Pharmacokinetics:

• Following oral administration, Buspirone is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1 to 1.5 hours.
• Buspirone undergoes extensive first-pass metabolism in the liver, primarily via the cytochrome P450 enzyme system, to form active metabolites.
• The elimination half-life of Buspirone and its metabolites ranges from 2 to 11 hours, allowing for multiple daily dosing to maintain therapeutic plasma concentrations.

Pharmacodynamics:

• Buspirone exerts its anxiolytic effects by selectively binding to presynaptic serotonin (5-HT1A) receptors, inhibiting serotonin reuptake, and enhancing neurotransmitter activity in the brain.
• By modulating serotonergic neurotransmission, Buspirone helps alleviate symptoms of anxiety, promote relaxation, and improve overall emotional well-being.

Side Effects:

• Common side effects associated with Buspirone may include dizziness, headache, nausea, nervousness, and insomnia.
• Less frequently reported adverse reactions may include gastrointestinal disturbances, lightheadedness, dry mouth, and fatigue.
• In rare instances, Buspirone may be associated with more serious adverse events such as serotonin syndrome, allergic reactions, or cardiovascular effects.

Trust in the efficacy and safety of Buspirone Hydrochloride Tablets from AIT Pharmaceuticals Division. Whether you are seeking relief from generalized anxiety disorder or managing acute anxiety symptoms, our product offers a reliable solution to help you regain control and lead a more fulfilling life. For more information, please visit our website or consult your healthcare provider.