Description

Drug Classification:

Divalproex sodium belongs to the class of drugs known as anticonvulsants and mood stabilizers. It is structurally composed of sodium valproate and valproic acid. Divalproex sodium works by increasing the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, which helps to reduce abnormal electrical activity and stabilize mood.

Formulations:

• Divalproex Sodium Tablets:
  • Strength: Available in 500mg tablets.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 100 tablets.

Indications:

Divalproex Sodium Tablets are indicated for the treatment of:

• Epilepsy: Divalproex sodium is used as an adjunctive therapy in the management of complex partial seizures and simple and complex absence seizures.
• Bipolar Disorder: Divalproex sodium is indicated for the treatment of manic episodes associated with bipolar disorder (manic-depressive illness).

Usage:

• Divalproex Sodium Tablets should be taken orally, with or without food, as directed by a healthcare professional.
• It is important to adhere to the prescribed dosage and dosing schedule to achieve optimal therapeutic outcomes.
• Dosage adjustments may be necessary based on individual response and tolerability, with close monitoring by a healthcare provider.

Dosage:

• The recommended initial dosage of Divalproex Sodium Tablets for epilepsy is typically 10 to 15mg/kg/day, divided into two or three doses.
• For the treatment of bipolar disorder, the initial dosage is usually 750mg daily, administered in divided doses.
• Dosage adjustments may be made based on clinical response and serum valproate concentrations, with a maximum recommended dosage of 60mg/kg/day.

Pharmacokinetics:

• Divalproex sodium is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 4 hours.
• The drug is extensively metabolized in the liver via glucuronidation and cytochrome P450-mediated oxidation.
• The elimination half-life of Divalproex sodium is approximately 9 to 16 hours, allowing for twice-daily or thrice-daily dosing regimens.

Pharmacodynamics:

• Divalproex sodium exerts its therapeutic effects by enhancing the inhibitory neurotransmission mediated by GABA in the central nervous system.
• By modulating neuronal excitability and inhibiting abnormal electrical activity, Divalproex sodium helps prevent seizure propagation and stabilize mood in patients with bipolar disorder.

Side Effects:

• Common side effects associated with Divalproex Sodium Tablets may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain.
• Other adverse reactions may include drowsiness, dizziness, tremor, weight gain, hair loss, and liver function abnormalities.
• In rare instances, Divalproex sodium may be associated with more serious adverse events such as hepatotoxicity, pancreatitis, thrombocytopenia, and encephalopathy.

Trust in the efficacy and safety of Divalproex Sodium Tablets from AIT Pharmaceuticals Division. Whether you are seeking seizure control or mood stabilization, our product offers a reliable solution to help you achieve optimal health and well-being. For more information, please visit our website or consult your healthcare provider.