Description

Product Description:

• Product Name: Tenofovir Disoproxil
• Drug Classification: Antiretroviral Agent
• Strength: 300 mg
• Product Form: Tablets
• Packing Specifications: 30’s
• Pharmacokinetics:

Tenofovir Disoproxil is rapidly absorbed from the gastrointestinal tract after oral administration and undergoes hydrolysis to its active form, tenofovir. Tenofovir is then phosphorylated intracellularly to its active metabolite, tenofovir diphosphate. The bioavailability of tenofovir disoproxil is approximately 25-40%. It has a long elimination half-life of approximately 17 hours, allowing for once-daily dosing.

Pharmacodynamics:

Tenofovir Disoproxil exerts its antiretroviral activity by inhibiting the activity of HIV reverse transcriptase, thereby blocking the replication of the HIV virus. It is also active against hepatitis B virus (HBV) by interfering with viral DNA synthesis. Tenofovir Disoproxil is effective against both HIV-1 and HIV-2 strains and has demonstrated potent antiviral activity in vitro.

Formulations:

Tenofovir Disoproxil is available in tablet form, with each tablet containing 300 mg of tenofovir disoproxil.

Indications:

HIV Infection: Tenofovir Disoproxil is indicated for the treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients weighing at least 17 kg.

Chronic Hepatitis B: Tenofovir Disoproxil is also indicated for the treatment of chronic hepatitis B virus infection in adults.

Usage:

HIV Infection: Tenofovir Disoproxil should be used in combination with other antiretroviral agents as part of a comprehensive regimen for the treatment of HIV-1 infection.

Chronic Hepatitis B: Tenofovir Disoproxil should be administered as a single daily dose for the treatment of chronic hepatitis B infection.

Dosage:

The recommended dosage of Tenofovir Disoproxil for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg is one 300 mg tablet once daily, taken orally with or without food. For patients weighing 17 to 35 kg, the recommended dosage is one 150 mg tablet once daily.

Side Effects:

Common side effects of Tenofovir Disoproxil may include nausea, diarrhea, headache, fatigue, and renal impairment. Patients should be monitored regularly for changes in renal function and bone mineral density. Rare but serious side effects may include lactic acidosis, hepatotoxicity, and exacerbation of hepatitis B upon discontinuation of treatment.

At AIT Pharmaceuticals Division, we are dedicated to providing safe and effective treatment options for patients living with HIV and hepatitis B. For more information about Tenofovir Disoproxil or any of our other products, please consult your healthcare provider or visit our website.