Description

Drug Classification:

Atorvastatin belongs to the class of medications known as statins, which are HMG-CoA reductase inhibitors. By inhibiting this enzyme, atorvastatin reduces the synthesis of cholesterol in the liver and lowers circulating levels of LDL cholesterol, thereby decreasing the risk of cardiovascular events.

Formulations:

• Atorvastatin Tablets:
  • Strengths: Available in 10mg, 20mg, and 40mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 28 tablets each.

Indications:

Atorvastatin Tablets are indicated for the:

• Treatment of hyperlipidemia (elevated levels of cholesterol and triglycerides) to reduce total cholesterol, LDL cholesterol, and apolipoprotein B levels.
• Prevention of cardiovascular events, including myocardial infarction, stroke, and coronary revascularization procedures, in patients with established coronary heart disease or other risk factors.

Usage:

• Atorvastatin Tablets should be taken orally, with or without food, as directed by a healthcare professional.
• The dosage regimen may vary depending on the patient’s lipid profile, cardiovascular risk factors, and individual response to therapy.
• Regular monitoring of lipid levels and liver function tests is recommended during treatment with atorvastatin to assess treatment efficacy and detect any potential adverse effects.

Dosage:

• The recommended starting dose of Atorvastatin is typically 10-20 mg once daily, with adjustments made based on the patient’s lipid levels and response to treatment.
• For patients requiring more aggressive lipid lowering, a starting dose of 40mg may be considered.
• Dosage should be individualized and titrated carefully to achieve optimal lipid control while minimizing the risk of adverse effects.

Pharmacokinetics:

• Atorvastatin is well absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver, where it is converted to its active form.
• The active metabolites of atorvastatin inhibit HMG-CoA reductase, leading to decreased cholesterol synthesis and increased clearance of LDL cholesterol from the bloodstream.

Pharmacodynamics:

• By reducing LDL cholesterol levels and promoting the clearance of atherogenic lipoproteins, atorvastatin helps prevent the progression of atherosclerosis and the occurrence of cardiovascular events.
• Additionally, atorvastatin exhibits anti-inflammatory and antioxidant properties that may contribute to its cardiovascular protective effects.

Side Effects:

• Common side effects associated with atorvastatin therapy may include headache, myalgia (muscle pain), gastrointestinal disturbances (nausea, diarrhea, constipation), and fatigue.
• Rare but serious adverse effects such as myopathy (muscle damage), rhabdomyolysis (severe muscle breakdown), and hepatotoxicity (liver damage) may occur and require prompt medical attention.

Experience the proven efficacy and cardiovascular benefits of AIT Pharmaceuticals Division’s Atorvastatin Tablets. For more information, please contact us. We are committed to promoting heart health and enhancing patient well-being through our pharmaceutical products.