Drug Classification:

Losartan Potassium, Hydrochlorothiazide Tablets belong to the class of medications known as angiotensin II receptor blockers (ARBs) combined with thiazide diuretics. This combination medication works synergistically to lower blood pressure through dual mechanisms, providing enhanced efficacy in the management of hypertension.

Formulations:

• Losartan Potassium, Hydrochlorothiazide Tablets:
  • Strength: Each tablet contains Losartan Potassium 50mg and Hydrochlorothiazide 12.5mg.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each.

Indications:

Losartan Potassium, Hydrochlorothiazide Tablets are indicated for:

• Treatment of hypertension (high blood pressure) in adults who require combination therapy to achieve blood pressure control.
• Reduction of cardiovascular morbidity and mortality in patients with hypertension and left ventricular hypertrophy.
• Management of heart failure in patients who are intolerant to angiotensin-converting enzyme (ACE) inhibitors.

Usage:

• Losartan Potassium, Hydrochlorothiazide Tablets should be taken orally once daily with or without food, as directed by a healthcare professional.
• It is essential to adhere to the prescribed dosage and administration regimen to achieve optimal blood pressure control and therapeutic outcomes.

Dosage:

• The recommended starting dose of Losartan Potassium, Hydrochlorothiazide Tablets for most patients with hypertension is one tablet (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) once daily.
• Dosage adjustment may be necessary based on individual patient response and tolerability, with a maximum dose of two tablets daily if needed.

Pharmacokinetics:

• Losartan Potassium is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. It undergoes hepatic metabolism to form its active metabolite, losartan carboxylic acid.
• Hydrochlorothiazide is readily absorbed from the gastrointestinal tract and excreted unchanged in the urine, exerting its diuretic effect by inhibiting sodium reabsorption in the distal convoluted tubule.

Pharmacodynamics:

• Losartan Potassium blocks the angiotensin II receptor subtype AT1, leading to vasodilation, reduced peripheral resistance, and decreased aldosterone secretion.
• Hydrochlorothiazide enhances diuresis by inhibiting sodium and chloride reabsorption in the distal tubules, resulting in increased excretion of sodium, chloride, and water, thereby lowering blood volume and blood pressure.

Side Effects:

• Common side effects associated with Losartan Potassium, Hydrochlorothiazide Tablets may include dizziness, headache, fatigue, and electrolyte disturbances (e.g., hypokalemia, hyponatremia).
• Rare but serious adverse effects such as renal dysfunction, hyperkalemia, and orthostatic hypotension may occur and require medical attention.
• Patients should be monitored regularly for electrolyte levels, renal function, and blood pressure control during treatment with Losartan Potassium, Hydrochlorothiazide Tablets.

Experience the combined benefits of Losartan Potassium and Hydrochlorothiazide in a single, convenient tablet formulation, exclusively from AIT Pharmaceuticals Division. For more information, please contact us. Your cardiovascular health is our priority, and we are committed to providing effective solutions for hypertension management.