Description

Drug Classification: Pantoprazole belongs to the class of proton pump inhibitors (PPIs), which exert their therapeutic effects by irreversibly blocking the hydrogen-potassium adenosine triphosphatase enzyme system in the gastric parietal cells, thereby reducing gastric acid secretion.

Formulations:

• Pantoprazole Capsules: Each capsule contains 40mg of pantoprazole, providing effective acid suppression for patients with gastroesophageal reflux disease (GERD) and other acid-related conditions.
• Pantoprazole General Dry Powder: Each vial contains 40mg of pantoprazole in dry powder form for reconstitution, facilitating administration via intravenous infusion.

Indications:

• Pantoprazole is indicated for the treatment of:
  • GERD, including erosive esophagitis
  • Duodenal and gastric ulcers
  • Zollinger-Ellison syndrome
  • Helicobacter pylori eradication in combination with appropriate antibiotics
  • Prevention of NSAID-induced gastric ulcers in high-risk patients

Pharmacokinetics:

• Absorption: Pantoprazole is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 2 hours.
• Distribution: It is extensively distributed throughout the body, with high concentrations found in the gastric parietal cells.
• Metabolism: Pantoprazole undergoes hepatic metabolism primarily by the cytochrome P450 enzyme system, with the main metabolites being inactive.
• Elimination: The elimination half-life of pantoprazole is approximately 1 hour, with the majority of the drug excreted in the urine.

Pharmacodynamics:

• Pantoprazole selectively inhibits the proton pump in the gastric parietal cells, leading to a profound and long-lasting suppression of gastric acid secretion. This mechanism of action provides rapid relief of symptoms and promotes healing of mucosal damage associated with acid-related disorders.

Usage:

• Pantoprazole capsules should be swallowed whole with water, preferably before meals.
• Pantoprazole general dry powder is reconstituted with sterile water for injection and administered as an intravenous infusion over a specified duration.

Dosage:

• The recommended dosage of pantoprazole varies depending on the indication and severity of the condition. It is typically administered once daily.

Side Effects:

• Common side effects of pantoprazole may include:
  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
• Serious side effects such as Clostridium difficile-associated diarrhea and hypomagnesemia may occur but are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Pantoprazole Range in the management of acid-related disorders. For more information, please contact us.