Description

Formulations:

• Metronidazole Tablets: Each tablet contains 400 mg of metronidazole, offering convenient oral administration for the treatment of various infections.
• Metronidazole Infusion: Available in a strength of 500mg per 100ml, our infusion provides a parenteral option for patients who cannot take oral medications.

Indications:

• Metronidazole is indicated for the treatment of:
  • Anaerobic bacterial infections, including intra-abdominal infections, bacterial vaginosis, and dental infections.
  • Protozoal infections, such as giardiasis, trichomoniasis, and amoebiasis.
  • Helicobacter pylori eradication in combination with other antimicrobial agents for the treatment of peptic ulcer disease and gastritis.

Pharmacokinetics:

• Absorption: Metronidazole is well absorbed after oral administration, with peak plasma concentrations achieved within 1-3 hours.
• Distribution: It penetrates well into various tissues and body fluids, including the central nervous system.
• Metabolism: Metronidazole undergoes hepatic metabolism via oxidation and glucuronidation.
• Elimination: The elimination half-life of metronidazole is approximately 6-8 hours, with the majority of the drug and its metabolites excreted in the urine.

Pharmacodynamics:

• Metronidazole exerts its antimicrobial effects by entering bacterial and protozoal cells, where it is reduced by intracellular electron transport proteins. The resulting reactive metabolites disrupt DNA structure, leading to inhibition of nucleic acid synthesis and ultimately cell death.

Usage:

• Metronidazole tablets should be taken orally with food to reduce gastrointestinal side effects.
• The infusion formulation is administered intravenously over a prescribed duration, typically 30-60 minutes, depending on the indication and patient’s condition.

Dosage:

• The dosage of metronidazole varies depending on the type and severity of the infection, as well as the patient’s age and weight.
• It is important to follow the dosage regimen prescribed by the healthcare provider to ensure optimal therapeutic outcomes.

Side Effects:

• Common side effects of metronidazole may include:
  • Nausea
  • Vomiting
  • Diarrhea
  • Metallic taste in the mouth
  • Headache
• Rare but serious side effects such as allergic reactions and peripheral neuropathy may occur, especially with prolonged use or high doses.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Metronidazole Range in the treatment of bacterial and protozoal infections. For more information, please contact us.