Description

Drug Classification: Anastrozole belongs to the class of drugs known as aromatase inhibitors. It works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens to estrogens in peripheral tissues, thereby reducing estrogen levels in the body.

Formulations:

• Anastrozole Tablets: Each tablet contains 1mg of Anastrozole, providing a convenient and precise dosage for patients.

Indications:

Anastrozole is indicated for the:

• Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.
• First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor-unknown locally advanced or metastatic breast cancer.
• Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Pharmacokinetics:

• Absorption: Anastrozole is rapidly and well absorbed after oral administration, with peak plasma concentrations achieved within 2 hours.
• Distribution: It is extensively distributed throughout the body, with a high volume of distribution indicating tissue distribution.
• Metabolism: Anastrozole is primarily metabolized in the liver via N-dealkylation, hydroxylation, and glucuronidation.
• Elimination: The elimination half-life of Anastrozole is approximately 50 hours, with the majority of the drug excreted in the urine and feces as metabolites.

Pharmacodynamics:

Anastrozole selectively inhibits aromatase, leading to decreased estrogen levels in postmenopausal women. This reduction in estrogen levels inhibits the growth of hormone receptor-positive breast cancer cells.

Usage:

• Anastrozole should be taken orally, usually once daily, with or without food.
• It is recommended to swallow the tablets whole with a glass of water.
• Patients should adhere to the prescribed dosage and duration of treatment as directed by their healthcare provider.

Dosage:

• The recommended dose of Anastrozole for adults is 1mg once daily.
• Dosage adjustments may be necessary in patients with hepatic impairment or other comorbidities. Consultation with a healthcare professional is advised.

Side Effects:

• Common side effects of Anastrozole may include:
  • Hot flashes
  • Fatigue
  • Joint pain
  • Headache
  • Nausea
  • Osteoporosis and bone fractures (long-term use)
• Serious side effects such as cardiovascular events and increased risk of endometrial cancer may occur but are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Anastrozole Range in the treatment of hormone receptor-positive breast cancer. For more information, please contact us.