Description

Drug Classification:

Alendronate belongs to the bisphosphonate class of medications. It acts as a potent inhibitor of bone resorption and is widely used in the management of osteoporosis and other bone-related disorders.

Formulations:

• Alendronate Tablets:
  • Strengths: Available in 10mg and 70mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 4 tablets each, ensuring ease of use and portability.

Indications:

Alendronate Tablets are indicated for the treatment and prevention of osteoporosis in postmenopausal women and men at risk of fractures. They are also used to increase bone mass in patients with glucocorticoid-induced osteoporosis.

Usage:

• Alendronate Tablets should be taken orally, preferably in the morning on an empty stomach, at least 30 minutes before the first food, beverage, or medication of the day.
• Patients should swallow the tablet whole with a full glass of plain water (not mineral water) while sitting or standing upright to prevent esophageal irritation.
• Avoid lying down for at least 30 minutes after taking the tablet to minimize the risk of esophageal adverse effects.

Dosage:

• The recommended dosage of Alendronate Tablets varies based on the indication and strength of the tablet.
• For the treatment of osteoporosis, the usual dose is one 70mg tablet once weekly or one 10mg tablet daily.
• Adequate intake of calcium and vitamin D is important during treatment to support bone health and minimize the risk of hypocalcemia.

Pharmacokinetics:

• Alendronate is poorly absorbed from the gastrointestinal tract, with an estimated oral bioavailability of less than 1%.
• Peak plasma concentrations are achieved within 0.5 to 2 hours after oral administration, with a terminal half-life of approximately 10 years due to its high affinity for bone tissue.

Pharmacodynamics:

• Alendronate inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite crystals in bone, thereby preventing their dissolution and reducing bone turnover.
• This leads to an increase in bone mineral density and a decrease in the risk of fractures, making it an essential therapy for osteoporosis management.

Side Effects:

• Common side effects of Alendronate Tablets may include gastrointestinal disturbances such as abdominal pain, nausea, and dyspepsia.
• Rare but serious adverse effects may include osteonecrosis of the jaw, atypical femoral fractures, and esophageal irritation.
• It is important to discuss any persistent or severe side effects with your healthcare provider.

Trust in the effectiveness and reliability of Alendronate Tablets from AIT Pharmaceuticals Division. We are committed to providing high-quality medications to support your bone health needs. For more information, please visit our website or consult your healthcare provider.