Description

Drug Classification:

Alendronate belongs to the bisphosphonate class of medications, while cholecalciferol is a form of vitamin D3. Together, they work synergistically to prevent bone loss and maintain bone mineral density, making this combination an essential therapy for osteoporosis management.

Formulations:

• Alendronate with Cholecalciferol Tablets:
  • Strength: Each tablet contains Alendronate Sodium equivalent to 70mg of Alendronate and Cholecalciferol 70 mcg (2800 IU).
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 7 tablets each, ensuring ease of use and portability.

Indications:

Alendronate with Cholecalciferol Tablets are indicated for the treatment and prevention of osteoporosis in postmenopausal women and men at risk of fractures. It is also used to increase bone mass in patients with glucocorticoid-induced osteoporosis.

Usage:

• Alendronate with Cholecalciferol Tablets should be taken orally, preferably in the morning on an empty stomach, at least 30 minutes before the first food, beverage, or medication of the day.
• Patients should swallow the tablet whole with a full glass of plain water (not mineral water) while sitting or standing upright to prevent esophageal irritation.
• Avoid lying down for at least 30 minutes after taking the tablet to minimize the risk of esophageal adverse effects.

Dosage:

• The recommended dosage of Alendronate with Cholecalciferol Tablets is one tablet once weekly.
• Adequate intake of calcium and vitamin D is important during treatment to support bone health and minimize the risk of hypocalcemia.
• Dose adjustment is not required based on age, gender, or renal function.

Pharmacokinetics:

• Alendronate is poorly absorbed from the gastrointestinal tract, with an estimated oral bioavailability of less than 1%.
• Cholecalciferol is absorbed in the small intestine and undergoes hydroxylation in the liver to form calcifediol (25-hydroxyvitamin D), which is then further metabolized to its active form, calcitriol (1,25-dihydroxyvitamin D), in the kidneys.

Pharmacodynamics:

• Alendronate inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite crystals in bone, thereby preventing their dissolution and reducing bone turnover.
• Cholecalciferol promotes calcium absorption in the intestine and mineralization of bone, supporting bone health and integrity.

Side Effects:

• Common side effects of Alendronate with Cholecalciferol Tablets may include gastrointestinal disturbances such as abdominal pain, nausea, and dyspepsia.
• Rare but serious adverse effects may include osteonecrosis of the jaw, atypical femoral fractures, and esophageal irritation.
• It is important to discuss any persistent or severe side effects with your healthcare provider.

Experience the comprehensive bone health benefits of Alendronate with Cholecalciferol Tablets from AIT Pharmaceuticals Division. Trust in our commitment to providing high-quality medications to support your bone health needs. For more information, please visit our website or consult your healthcare provider.