Description

Drug Classification:

Amisulpride belongs to the class of medications known as atypical antipsychotics. It exerts its therapeutic effects by blocking dopamine D2 and D3 receptors in the brain, thereby modulating dopamine neurotransmission. This mechanism helps alleviate symptoms associated with psychiatric disorders such as schizophrenia and major depressive disorder.

Formulations:

• Amisulpride Tablets:
  • Strength: Available in multiple strengths to suit individual patient needs.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 10 tablets.

Indications:

Amisulpride Tablets are indicated for the treatment of various psychiatric disorders, including:

• Schizophrenia: Amisulpride effectively manages positive symptoms (such as hallucinations and delusions) and negative symptoms (such as social withdrawal and apathy) of schizophrenia.
• Major Depressive Disorder (MDD): In lower doses, Amisulpride demonstrates antidepressant properties and may be used to treat depressive episodes associated with MDD.

Usage:

• Amisulpride Tablets should be taken orally as directed by a healthcare professional.
• The dosage and duration of treatment may vary depending on the specific psychiatric condition being treated, as well as individual patient response.
• It is essential to adhere to the prescribed dosage regimen and continue treatment as directed, even if symptoms improve.

Dosage:

• The recommended dosage of Amisulpride varies depending on the indication and severity of the psychiatric condition.
• For schizophrenia, the usual starting dosage ranges from 400mg to 800mg per day, divided into multiple doses.
• In the treatment of major depressive disorder, lower doses of Amisulpride (50mg to 300mg per day) may be used, administered as a single daily dose.

Pharmacokinetics:

• Amisulpride is well absorbed following oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• It undergoes extensive hepatic metabolism, primarily via sulfoxidation and hydroxylation pathways, resulting in the formation of inactive metabolites.
• The elimination half-life of Amisulpride is approximately 12 hours, allowing for once or twice-daily dosing to maintain therapeutic plasma concentrations.

Pharmacodynamics:

• Amisulpride primarily acts as a selective antagonist of dopamine D2 and D3 receptors in the brain, exerting both antipsychotic and antidepressant effects.
• By blocking these receptors, Amisulpride modulates dopamine neurotransmission, leading to a reduction in psychotic symptoms and improvements in mood and cognition.

Side Effects:

• Common side effects associated with Amisulpride treatment may include extrapyramidal symptoms (such as akathisia, dystonia, and parkinsonism), sedation, and weight gain.
• Less frequently observed adverse reactions may include hyperprolactinemia, orthostatic hypotension, and gastrointestinal disturbances.
• In rare cases, Amisulpride may cause more serious adverse events such as neuroleptic malignant syndrome (NMS) or QT prolongation.

Trust in the efficacy and safety of Amisulpride Tablets from AIT Pharmaceuticals Division. We are dedicated to supporting patients with psychiatric disorders and providing them with effective treatment options to improve their mental health. For more information, please visit our website or consult your healthcare provider.