Description

Drug Classification:

Amlodipine as Besylate Tablets belongs to the class of medications known as calcium channel blockers. This class of drugs works by relaxing and widening blood vessels, thereby improving blood flow and lowering blood pressure. Amlodipine specifically acts on the smooth muscle cells of blood vessels, inhibiting calcium influx and promoting vasodilation.

Formulations:

• Amlodipine as Besylate Tablets:
  • Strength: Each tablet contains Amlodipine as Besylate 5mg or 10mg.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each.

Indications:

Amlodipine as Besylate Tablets are indicated for:

• Treatment of hypertension (high blood pressure) to lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack.
• Management of chronic stable angina (chest pain) and vasospastic angina (Prinzmetal’s or variant angina) to improve exercise tolerance and reduce the frequency of angina attacks.

Usage:

• Amlodipine as Besylate Tablets should be taken orally once daily with or without food, as directed by a healthcare professional.
• It is important to adhere to the prescribed dosage and administration regimen to achieve optimal blood pressure control and therapeutic outcomes.

Dosage:

• The recommended starting dose of Amlodipine as Besylate Tablets for most patients with hypertension or angina is 5mg once daily.
• Dosage adjustment may be necessary based on individual patient response and tolerability, with a maximum dose of 10mg once daily for hypertension and 10mg once daily for angina.

Pharmacokinetics:

• Amlodipine is well absorbed after oral administration, with peak plasma concentrations reached within 6 to 12 hours. It undergoes extensive hepatic metabolism, with approximately 90% of the drug eliminated in the urine as metabolites.
• The elimination half-life of Amlodipine is approximately 30 to 50 hours, allowing for once-daily dosing and consistent blood pressure control.

Pharmacodynamics:

• Amlodipine exerts its therapeutic effects by selectively inhibiting calcium influx through voltage-sensitive L-type calcium channels in smooth muscle cells of blood vessels and cardiac muscle.
• By blocking calcium entry, Amlodipine promotes vasodilation of peripheral arterioles, reducing systemic vascular resistance and lowering blood pressure without affecting heart rate or cardiac conduction.

Side Effects:

• Common side effects associated with Amlodipine as Besylate Tablets may include peripheral edema, headache, dizziness, flushing, and fatigue.
• Rare but serious adverse effects such as hypotension, bradycardia, and peripheral neuropathy may occur and require medical attention.
• Patients should be monitored regularly for blood pressure, heart rate, and signs of peripheral edema during treatment with Amlodipine as Besylate Tablets.

Experience the proven efficacy and safety of Amlodipine for the management of hypertension and angina, exclusively from AIT Pharmaceuticals Division. For more information, please contact us. Your cardiovascular health is our priority, and we are dedicated to providing effective solutions for optimal patient care.