Description

Formulations:

• Celecoxib Capsules:
  • Strength: Available in 200mg capsules
  • Product Form: Oral capsules for convenient administration
  • Packing Specifications: Each pack contains 20 capsules

Indications:

Celecoxib is indicated for the treatment of various painful and inflammatory conditions, including:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute gouty arthritis
• Acute pain (including menstrual pain)
• Primary dysmenorrhea

Usage:

• Celecoxib capsules should be taken orally with a full glass of water, preferably with or after food to minimize gastrointestinal irritation.
• The dosage and duration of treatment may vary depending on the specific condition being treated, the patient’s response to therapy, and other individual factors.

Dosage:

• The recommended dosage of Celecoxib for most indications is 200 mg once daily.
• In some cases, a higher dose of up to 400 mg daily may be prescribed for acute pain relief.
• Dosage adjustments may be necessary in elderly patients, patients with hepatic impairment, or those with renal impairment.

Pharmacokinetics:

• Absorption: Celecoxib is well absorbed after oral administration, with peak plasma concentrations achieved within 3 hours.
• Distribution: The drug is extensively protein-bound (more than 97%) and is distributed throughout the body.
• Metabolism: Celecoxib undergoes hepatic metabolism primarily via the cytochrome P450 enzyme CYP2C9.
• Elimination: The elimination half-life of Celecoxib is approximately 11 hours. It is primarily excreted in the feces and urine, mainly as metabolites.

Pharmacodynamics:

• Celecoxib selectively inhibits COX-2, leading to suppression of prostaglandin synthesis. By reducing inflammation and pain, it provides relief to patients suffering from various musculoskeletal conditions.

Side Effects:

• Common side effects of Celecoxib may include:
  • Gastrointestinal disturbances (e.g., dyspepsia, abdominal pain)
  • Headache
  • Dizziness
  • Edema
  • Hypertension
• Serious adverse reactions such as gastrointestinal bleeding, ulceration, and cardiovascular events may occur, particularly with long-term use or high doses.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Celecoxib Range in the management of pain and inflammation. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals