Description

Product Description:

• Product Name: Clozapine
• Drug Classification: Atypical Antipsychotic
• Strengths: 25 mg and 100 mg
• Product Form: Tablets
• Packing Specifications: 10’s and 50’s

Pharmacokinetics:

Clozapine is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1.5 to 2 hours. It undergoes extensive metabolism in the liver, primarily via the cytochrome P450 system, to inactive metabolites. The elimination half-life of clozapine ranges from 6 to 33 hours, allowing for once or twice daily dosing depending on the individual’s response and tolerance.

Pharmacodynamics:

Clozapine exerts its therapeutic effects through antagonism of multiple neurotransmitter receptors, including dopamine D2, serotonin 5-HT2A, histamine H1, and adrenergic α1 receptors. By modulating neurotransmitter activity in the brain, clozapine effectively alleviates symptoms of psychosis, including hallucinations, delusions, and disorganized thinking, while also improving mood and cognitive function.

Formulations:

Clozapine is available in tablet form, with two strengths: 25 mg and 100 mg. The tablets are designed for oral administration and are available in packs of 10’s and 50’s for convenience.

Indications:

Clozapine is indicated for the treatment of schizophrenia in patients who are unresponsive to or intolerant of other antipsychotic medications. It is also effective in reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder.

Usage:

Clozapine should be initiated and titrated gradually under the supervision of a qualified healthcare professional experienced in the management of psychotic disorders. The dosage should be adjusted based on the individual patient’s response and tolerance. Regular monitoring of blood counts, particularly for agranulocytosis, is essential during treatment with clozapine.

Dosage:

Initial Dosage: The recommended starting dose of clozapine is 12.5 mg once or twice daily. The dosage should be increased gradually over several weeks to achieve the desired therapeutic effect while minimizing the risk of adverse reactions.

Maintenance Dosage: Most patients require maintenance doses ranging from 300 mg to 900 mg per day, divided into two or three doses. However, individual dosage requirements may vary, and the optimal dose should be determined based on clinical response and tolerability.

Side Effects:

Common side effects of clozapine may include sedation, dizziness, weight gain, constipation, and sialorrhea (excessive saliva production). More serious adverse reactions may include agranulocytosis (severe neutropenia), myocarditis, seizures, and metabolic disturbances. Patients should be closely monitored for signs of agranulocytosis, particularly during the first few months of treatment.

At AIT Pharmaceuticals Division, we are dedicated to providing effective and safe treatment options for individuals living with psychiatric disorders. Clozapine represents our commitment to innovation and patient care. For more information about Clozapine or any of our other products, please consult your healthcare provider or visit our website.