Description

Drug Classification:

Enalapril belongs to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors. It works by inhibiting the enzyme ACE, thereby reducing the production of angiotensin II, a potent vasoconstrictor. By blocking the effects of angiotensin II, Enalapril helps to relax blood vessels, lower blood pressure, and improve cardiac function.

Formulations:

• Enalapril as Maleate Tablets:
  • Strength: Available in three strengths – 5mg, 10mg, and 20mg tablets.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each, ensuring ease of storage and use.

Indications:

Enalapril as Maleate Tablets is indicated for the following conditions:

• Hypertension (High Blood Pressure): Enalapril is used to treat hypertension, a condition characterized by elevated blood pressure levels. By lowering blood pressure, Enalapril helps reduce the risk of cardiovascular events such as stroke and heart attack.
• Heart Failure: Enalapril is prescribed for the management of heart failure, a condition in which the heart is unable to pump blood effectively. By reducing the workload on the heart and improving cardiac function, Enalapril helps alleviate symptoms and improve quality of life in patients with heart failure.

Usage:

• Enalapril Tablets should be taken orally, with or without food, as directed by your healthcare provider.
• It is essential to adhere to the prescribed dosage and regimen recommended by your healthcare provider.
• Do not discontinue Enalapril without consulting your doctor, as sudden discontinuation may lead to worsening of symptoms.

Dosage:

• The recommended dosage of Enalapril depends on the indication for which it is prescribed and the patient’s individual response to treatment.
• For the treatment of hypertension, the usual starting dose is 5mg once daily, with dosage adjustments made based on blood pressure response.
• For heart failure, the initial dose may be lower, with gradual titration based on the patient’s tolerance and clinical status.

Pharmacokinetics:

• Enalapril is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
• The drug undergoes hepatic metabolism to its active form, Enalaprilat, which exerts pharmacological effects.
• Enalaprilat is primarily eliminated via the kidneys, with an elimination half-life of approximately 11 hours in patients with normal renal function.

Pharmacodynamics:

• Enalapril inhibits the enzyme ACE, thereby preventing the conversion of angiotensin I to angiotensin II.
• By reducing the production of angiotensin II, Enalapril promotes vasodilation, decreases peripheral vascular resistance, and lowers blood pressure.
• Additionally, Enalapril may also exert cardioprotective effects by reducing cardiac remodeling and improving myocardial function in patients with heart failure.

Side Effects:

• Common side effects of Enalapril may include dizziness, headache, fatigue, dry cough, and hypotension (low blood pressure).
• Less common but more serious side effects may include hyperkalemia (high potassium levels), renal impairment, and angioedema (swelling of the face, lips, or throat).
• Contact your healthcare provider immediately if you experience severe or persistent side effects while taking Enalapril.

Experience the effectiveness and safety of Enalapril as Maleate Tablets from AIT Pharmaceuticals Division. Trust in our commitment to delivering pharmaceutical excellence and improving patient care. For more information, please visit our website or consult your healthcare provider.