Description

Drug Classification:

Fexofenadine is classified as a second-generation antihistamine. It belongs to the class of medications known as selective histamine H1-receptor antagonists, which work by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Formulations:

• Fexofenadine Tablets:
  • Strengths: Available in 60mg, 120mg, and 180mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 10 tablets each, with outer packaging available in packs of 28 tablets.

Indications:

Fexofenadine Tablets are indicated for the relief of symptoms associated with seasonal allergic rhinitis (hay fever) and perennial allergic rhinitis. These symptoms may include sneezing, runny or itchy nose, itchy or watery eyes, and itching of the throat or palate.

Usage:

• Fexofenadine Tablets should be taken orally with water, preferably with or without food.
• The medication is typically used on an as-needed basis to relieve allergy symptoms promptly.
• It is essential to follow the instructions provided by a healthcare professional regarding the timing and frequency of dosing.

Dosage:

• The recommended dosage of Fexofenadine depends on the strength of the tablet:
  • For adults and children aged 12 years and older: 60 mg or 180 mg once daily.
  • For children aged 6 to 11 years: 30mg twice daily or 60 mg once daily.
  • Dosage adjustments may be necessary based on individual patient response and tolerability.
• It is important not to exceed the recommended dose to avoid adverse effects.

Pharmacokinetics:

• Absorption: Fexofenadine is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations achieved within 2 to 3 hours.
• Distribution: The drug is distributed extensively throughout the body, including to target tissues in the respiratory tract and skin.
• Metabolism: Fexofenadine undergoes minimal metabolism in the liver, primarily via oxidation and glucuronidation, with the majority of the unchanged drug excreted in the urine.
• Elimination: The elimination half-life of Fexofenadine ranges from 14 to 16 hours in adults, allowing for once-daily dosing.

Pharmacodynamics:

• Fexofenadine exerts its therapeutic effects by selectively antagonizing histamine H1 receptors, thereby preventing the actions of histamine on target cells and tissues. This results in the alleviation of allergic symptoms without causing significant sedation or anticholinergic effects.

Side Effects:

• Common side effects of Fexofenadine may include headache, drowsiness, nausea, and dry mouth.
• Rare but serious side effects may include allergic reactions, arrhythmias, and liver dysfunction.
• It is important to consult a healthcare professional if any adverse reactions occur during treatment with Fexofenadine.

Experience the relief provided by AIT Pharmaceuticals Division’s Fexofenadine Tablets for allergy management. For more information, please contact us. We are dedicated to providing effective pharmaceutical solutions to healthcare professionals worldwide.