Description

Drug Classification:

Gabapentin Capsules belong to the class of drugs known as anticonvulsants or antiepileptic drugs (AEDs). While originally developed to treat epilepsy, Gabapentin is also effective in managing neuropathic pain and certain types of seizures.

Formulations:

• Gabapentin Capsules:

• • Strengths: Available in 100mg, 300mg, and 400mg formulations.
  • Product Form: Oral capsules for convenient administration.
  • Packing Specs: Each pack contains 10 capsules.

Indications:

Gabapentin Capsules are indicated for the treatment of the following conditions:

• Epilepsy: Gabapentin is effective as adjunctive therapy in the treatment of partial seizures with or without secondary generalization in adults and pediatric patients.
• Neuropathic Pain: This medication is also indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and other neuropathic conditions.
• Restless Legs Syndrome (RLS): Gabapentin may be used off-label for the treatment of RLS, providing relief from uncomfortable sensations in the legs and improving sleep quality.

Usage:

• Gabapentin Capsules should be taken orally with water, with or without food.
• It is important to follow the prescribed dosage and dosing schedule as directed by a healthcare professional.
• Capsules should be swallowed whole and not crushed, chewed, or opened, as this may affect the release of the medication.

Dosage:

• The recommended starting dose of Gabapentin for epilepsy is typically 300mg to 900 mg per day, divided into three doses.
• For neuropathic pain, the starting dose is usually 300 mg once daily on day 1, 300 mg twice daily on day 2, and 300 mg three times daily on day 3.
• Dosage adjustments may be made based on individual response and tolerability, with a maximum recommended dose of 3600 mg per day.

Pharmacokinetics:

• Gabapentin is absorbed in the small intestine via the L-amino acid transport system, with peak plasma concentrations achieved within 2 to 3 hours after administration.
• It does not undergo significant metabolism and is primarily eliminated unchanged in the urine.
• The elimination half-life of Gabapentin is approximately 5 to 7 hours in adults and 4 to 6 hours in children.

Pharmacodynamics:

• Gabapentin exerts its antiepileptic and analgesic effects by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system.
• This mechanism of action reduces the release of excitatory neurotransmitters, such as glutamate, and inhibits neuronal hyperexcitability, thereby suppressing seizures and modulating pain transmission.

Side Effects:

• Common side effects associated with Gabapentin Capsules may include dizziness, somnolence, fatigue, ataxia, and peripheral edema.
• Less common but potentially serious side effects may include respiratory depression, suicidal ideation, and hypersensitivity reactions.
• Patients should be advised to report any new or worsening symptoms to their healthcare provider promptly.

Trust in the efficacy and safety of Gabapentin Capsules from AIT Pharmaceuticals Division. Whether you are managing epilepsy, neuropathic pain, or restless legs syndrome, our product offers a reliable solution to help you achieve symptom control and improve your quality of life. For more information, please visit our website or consult your healthcare provider.