Description

Drug Classification:

Glimepiride belongs to the sulfonylurea class of antidiabetic agents. It works by stimulating the release of insulin from pancreatic beta cells, thereby increasing insulin secretion and reducing blood glucose levels.

Formulations:

• Glimepiride Tablets:
  • Strength: Available in four formulations:
    • Glimepiride 1mg Tablets (20’s)
    • Glimepiride 2mg Tablets (20’s)
    • Glimepiride 3mg Tablets (20’s)
    • Glimepiride 4mg Tablets (20’s)
  • Product Form: Oral tablets for easy administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each, ensuring convenience and freshness.

Indications:

Glimepiride Tablets are indicated for the treatment of type 2 diabetes mellitus in adults. They are used as an adjunct to diet and exercise to improve glycemic control in patients whose blood glucose levels are not adequately controlled with lifestyle modifications alone.

Usage:

• Glimepiride Tablets should be taken orally once daily, preferably with breakfast or the first main meal of the day.
• It is essential to follow the prescribed dosage and regimen recommended by your healthcare provider.
• Regular monitoring of blood glucose levels is necessary to assess treatment efficacy and adjust dosage as needed.

Dosage:

• The dosage of Glimepiride Tablets may vary depending on the patient’s individual response to treatment, glycemic control goals, and renal function.
• The usual starting dose is 1 to 2 mg once daily, with gradual titration based on blood glucose levels and tolerance.
• The maximum recommended dose is 8 mg once daily.

Pharmacokinetics:

• Glimepiride is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 2-3 hours.
• It is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, and undergoes renal and biliary excretion.
• The elimination half-life of Glimepiride is approximately 5-9 hours.

Pharmacodynamics:

• Glimepiride acts by binding to sulfonylurea receptors on pancreatic beta cells, leading to the closure of ATP-sensitive potassium channels and subsequent depolarization of the cell membrane.
• This depolarization triggers the influx of calcium ions, which stimulates the release of insulin from pancreatic beta cells, thereby lowering blood glucose levels.

Side Effects:

• Common side effects of Glimepiride Tablets may include hypoglycemia (low blood sugar), gastrointestinal symptoms such as nausea and diarrhea, and weight gain.
• Rare but serious side effects may include severe hypoglycemia, allergic reactions, and liver dysfunction.
• Contact your healthcare provider immediately if you experience any severe or persistent side effects while taking Glimepiride Tablets.

Experience the efficacy and convenience of Glimepiride Tablets from AIT Pharmaceuticals Division. Trust in our commitment to providing quality medications to improve the lives of patients with type 2 diabetes mellitus. For more information, please visit our website or consult your healthcare provider.