Drug Classification:

Itopride HCl belongs to the class of drugs known as prokinetic agents. It exerts its therapeutic effects by enhancing gastrointestinal motility and accelerating gastric emptying, making it a valuable option for the management of various gastrointestinal conditions.

Formulations:

• Itopride HCl Tablets:
  • Strength: 25mg and 50mg
  • Product Form: Oral tablets
  • Packing Specifications: Available in blister packs of 10 tablets

Indications:

Itopride HCl is indicated for the treatment of various gastrointestinal disorders, including:

• Functional dyspepsia
• Gastroesophageal reflux disease (GERD)
• Non-ulcer dyspepsia
• Gastroparesis
• Nausea and vomiting associated with various conditions

Usage:

• Itopride HCl tablets should be taken orally with or without food, as directed by the healthcare provider.
• The tablets should be swallowed whole with a glass of water and should not be chewed or crushed.
• It is essential to adhere to the prescribed dosage and duration of treatment for optimal therapeutic outcomes.

Dosage:

• The recommended dosage of Itopride HCl may vary depending on the patient’s age, weight, and the severity of the condition being treated.
• Typically, the usual adult dosage ranges from 50mg to 100mg three times daily before meals.
• Pediatric dosages should be determined based on the child’s weight and the healthcare provider’s recommendation.

Pharmacokinetics:

• Absorption: Itopride HCl is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours.
• Distribution: The drug is extensively distributed into various tissues, including the gastrointestinal tract, where it exerts its pharmacological effects.
• Metabolism: Itopride HCl undergoes extensive metabolism in the liver, primarily by CYP3A4 and CYP2D6 enzymes.
• Elimination: The elimination half-life of Itopride HCl is approximately 6-7 hours, with the majority of the drug and its metabolites excreted in the urine.

Pharmacodynamics:

• Itopride HCl exerts its pharmacological effects by inhibiting acetylcholinesterase activity, thereby enhancing the release of acetylcholine and promoting gastrointestinal motility.

Side Effects:

• Common side effects of Itopride HCl may include:
  • Gastrointestinal disturbances, such as diarrhea, abdominal pain, and nausea
  • Headache
  • Dizziness
  • Fatigue
• Serious adverse reactions are rare but may include allergic reactions and cardiac arrhythmias.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Itopride HCl Range in the management of gastrointestinal disorders. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals