Pharmacokinetics:

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic and anti-inflammatory properties. When administered as an ophthalmic solution, Ketorolac exerts its therapeutic effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the production of prostaglandins, which are mediators of pain and inflammation. Following topical application to the eye, Ketorolac is rapidly absorbed into the ocular tissues, providing localized relief from ocular discomfort and inflammation.

Pharmacodynamics:

Ketorolac ophthalmic solution acts locally within the eye to alleviate pain and inflammation associated with various ocular conditions, including postoperative inflammation following ocular surgery and seasonal allergic conjunctivitis. By suppressing the synthesis of prostaglandins, Ketorolac effectively reduces ocular discomfort, redness, swelling, and photophobia, promoting rapid relief and improved visual comfort.

Drug Classification:

Ketorolac belongs to the class of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically indicated for ophthalmic use. It is classified as a potent analgesic and anti-inflammatory agent that provides effective relief from ocular pain and inflammation without the systemic side effects associated with corticosteroids.

Formulations:

AIT Pharmaceuticals Division offers Ketorolac Ophthalmic Solution in the following formulation:

• Eye Drops: Each ml contains 0.005 mg of Ketorolac in a sterile ophthalmic solution, packed in a convenient dropper bottle with a capacity of 5 ml.

Indications:

Ketorolac Ophthalmic Solution is indicated for the temporary relief of ocular pain and inflammation following ophthalmic surgery, including cataract extraction and refractive surgery. It is also indicated for the treatment of seasonal allergic conjunctivitis (hay fever), characterized by ocular itching, redness, and swelling.

Usage:

To use Ketorolac Ophthalmic Solution, wash your hands thoroughly and tilt your head back. Gently pull down the lower eyelid to create a small pocket and hold the dropper bottle upside down. Instill one drop of the solution into the affected eye(s) while avoiding contact with the dropper tip to prevent contamination. Blink gently to distribute the medication evenly and repeat the process if necessary.

Dosage:

The recommended dosage of Ketorolac Ophthalmic Solution is one drop instilled into the affected eye(s) four times daily, or as directed by your healthcare provider. Do not exceed the prescribed dosage, as prolonged use may increase the risk of adverse effects.

Side Effects:

Common side effects of Ketorolac Ophthalmic Solution may include temporary stinging or burning sensation upon instillation, eye irritation, itching, redness, and blurred vision. Rare but serious side effects may include corneal epithelial defects, ocular surface disorders, and delayed wound healing. If you experience any persistent or severe side effects, discontinue use of the medication and consult your healthcare provider promptly.

Trust AIT Pharmaceuticals Division’s Ketorolac Ophthalmic Solution to provide effective relief from ocular pain and inflammation, ensuring optimal comfort and visual clarity. With our unwavering commitment to excellence and patient satisfaction, we strive to improve ocular health and enhance quality of life for individuals worldwide.