Description

Drug Classification:

Lamotrigine belongs to the class of drugs known as anticonvulsants or antiepileptic drugs. It acts by stabilizing neuronal membranes and inhibiting the release of excitatory neurotransmitters, thereby reducing abnormal electrical activity in the brain. Additionally, Lamotrigine exhibits mood-stabilizing properties, making it beneficial for the treatment of bipolar disorder.

Formulations:

• Lamotrigine Tablets:
  • Strength: Available in 50mg and 100mg tablets.
  • Product Form: Oral tablets for easy administration.
  • Packing Specs: Each pack contains 30 tablets.

Indications:

Lamotrigine Tablets are indicated for the treatment of:

• Epilepsy: Lamotrigine is used as an adjunctive therapy or as monotherapy in the treatment of partial seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome.
• Bipolar Disorder: Lamotrigine is indicated for the maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults.

Usage:

• Lamotrigine Tablets should be taken orally with or without food, as directed by a healthcare professional.
• It is important to follow the prescribed dosage and dosing schedule carefully to achieve optimal therapeutic effects.
• Dosage adjustments may be necessary based on individual response and tolerability, with close monitoring by a healthcare provider.

Dosage:

• For epilepsy:
  • Starting dosage: The recommended initial dosage is typically 25mg once daily for the first two weeks, followed by a gradual titration based on response and tolerability.
  • Maintenance dosage: The usual maintenance dosage ranges from 100mg to 400mg daily, administered in divided doses.
• For bipolar disorder:
  • Starting dosage: The initial dosage depends on whether Lamotrigine is used as monotherapy or adjunctive therapy and the presence of concomitant medications.
  • Maintenance dosage: The maintenance dosage typically ranges from 100mg to 200mg daily.

Pharmacokinetics:

• Lamotrigine is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1.4 to 4.8 hours.
• The drug is extensively metabolized in the liver via glucuronidation, with renal excretion of metabolites.
• The elimination half-life of Lamotrigine is approximately 24 to 35 hours in adults, allowing for once-daily or twice-daily dosing regimens.

Pharmacodynamics:

• Lamotrigine exerts its therapeutic effects by stabilizing neuronal membranes and inhibiting the release of excitatory neurotransmitters, such as glutamate and aspartate.
• By reducing abnormal electrical activity in the brain, Lamotrigine helps prevent seizures and stabilize mood in patients with bipolar disorder.

Side Effects:

• Common side effects associated with Lamotrigine Tablets may include headache, dizziness, somnolence, nausea, vomiting, blurred vision, and rash.
• Serious adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and aseptic meningitis have been reported rarely.
• It is essential to monitor for signs of hypersensitivity reactions, especially during the initial weeks of treatment.

Trust in the efficacy and safety of Lamotrigine Tablets from AIT Pharmaceuticals Division. Whether you are managing epilepsy or bipolar disorder, our product offers a reliable solution to help you lead a fulfilling life. For more information, please visit our website or consult your healthcare provider.