Description

Drug Classification: Lansoprazole belongs to the class of proton pump inhibitors (PPIs), which work by irreversibly inhibiting the hydrogen-potassium adenosine triphosphatase enzyme system in the gastric parietal cells, thereby reducing gastric acid secretion.

Formulations:

• Lansoprazole Capsules: Available in a convenient capsule form, each containing 30mg of Lansoprazole, ensuring precise dosing for patients.
• Lansoprazole General Dry Powder Injection: Each vial contains 30mg of Lansoprazole for intravenous administration, offering rapid relief for patients unable to take oral medication.

Indications:

Lansoprazole is indicated for the:

• Treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis.
• Maintenance of healing of erosive esophagitis.
• Treatment of duodenal ulcers and gastric ulcers.
• Reduction of risk of gastric ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients at risk.

Pharmacokinetics:

• Absorption: Lansoprazole is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours.
• Distribution: It is extensively distributed throughout the body, including the gastrointestinal tract.
• Metabolism: Lansoprazole undergoes hepatic metabolism via the cytochrome P450 enzyme system, primarily by CYP2C19 and CYP3A4.
• Elimination: The elimination half-life of Lansoprazole is approximately 1-2 hours, with the majority of the drug excreted in the urine as metabolites.

Pharmacodynamics:

Lansoprazole inhibits the proton pump in the gastric parietal cells, resulting in a profound and prolonged suppression of gastric acid secretion. This mechanism of action provides effective relief from symptoms of acid-related disorders and promotes healing of damaged mucosa.

Usage:

• Lansoprazole capsules should be taken orally, usually once daily, with or without food.
• The general dry powder injection is administered intravenously over a period of 10-30 minutes, as directed by a healthcare professional.

Dosage:

• The recommended dosage of Lansoprazole for adults varies depending on the indication and severity of the condition.
• Common dosages include 30 mg once daily for the treatment of GERD and maintenance of healing of erosive esophagitis.

Side Effects:

• Common side effects of Lansoprazole may include:
  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhea
  • Flatulence
• Serious side effects such as Clostridium difficile-associated diarrhea and hypomagnesemia may occur but are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Lansoprazole Range in the management of acid-related disorders. For more information, please contact us.