Description

Drug Classification:

Levosulpiride is classified as a selective dopamine D2 receptor antagonist. It exerts its therapeutic effects by blocking dopamine receptors in the central nervous system, leading to an increase in the release of acetylcholine, which helps regulate gastrointestinal motility and reduces symptoms associated with psychiatric disorders.

Formulations:

• Levosulpiride Tablets:
  • Strength: 25mg and 50mg
  • Product Form: Oral tablets
  • Packing Specifications: Available in blister packs of 20 tablets

Indications:

Levosulpiride is indicated for the treatment of various medical conditions, including:

• Gastrointestinal disorders: Levosulpiride is used to manage symptoms of dyspepsia, gastroesophageal reflux disease (GERD), and functional dyspepsia.
• Psychiatric disorders: Levosulpiride is also used in the management of psychiatric conditions such as depression, anxiety disorders, and psychosis.

Usage:

• Levosulpiride tablets should be taken orally with water, preferably before meals.
• The dosage and duration of treatment may vary depending on the patient’s age, weight, medical condition, and response to therapy.
• It is essential to adhere to the prescribed dosage and follow the healthcare provider’s recommendations for optimal therapeutic outcomes.

Dosage:

• The recommended dosage of Levosulpiride may vary depending on the indication being treated.
• For gastrointestinal disorders, the usual adult dosage ranges from 25mg to 50mg taken two to three times daily.
• For psychiatric disorders, the dosage may range from 25mg to 100mg taken two to three times daily, as determined by the healthcare provider.

Pharmacokinetics:

• Absorption: Levosulpiride is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours.
• Distribution: The drug is widely distributed throughout the body, including the central nervous system.
• Metabolism: Levosulpiride undergoes extensive hepatic metabolism, primarily by the cytochrome P450 enzyme system.
• Elimination: The elimination half-life of Levosulpiride is approximately 6-8 hours, with the majority of the drug and its metabolites excreted in the urine.

Pharmacodynamics:

• Levosulpiride exerts its pharmacological effects by blocking dopamine receptors in the central nervous system, leading to an increase in the release of acetylcholine. This enhances gastrointestinal motility and regulates mood and behavior in psychiatric disorders.

Side Effects:

• Common side effects of Levosulpiride may include:
  • Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea
  • Drowsiness or sedation
  • Dizziness
  • Headache
• Serious adverse reactions are rare but may include extrapyramidal symptoms, hyperprolactinemia, and cardiac arrhythmias.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Levosulpiride Range in the management of gastrointestinal and psychiatric disorders. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.