Description

Drug Classification:

Loperamide belongs to the class of medications known as antidiarrheals. It acts locally on the intestinal wall, slowing down gut motility and reducing fluid secretion, thereby alleviating diarrhea. By targeting the underlying cause of diarrhea, loperamide provides symptomatic relief and helps restore normal bowel function.

Formulations:

• Loperamide HCl Tablets:
  • Strength: Each tablet contains 2 mg of loperamide hydrochloride.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 60 tablets.

Indications:

Loperamide HCl Tablets are indicated for the symptomatic treatment of acute and chronic diarrhea in adults and children over 6 years of age. It is recommended for the management of diarrhea associated with various etiologies, including viral or bacterial infections, inflammatory bowel disease, and irritable bowel syndrome.

Usage:

• Loperamide HCl Tablets should be taken orally with water, as directed by a healthcare provider or according to the instructions provided on the packaging.
• It is essential to follow the recommended dosage and treatment duration to achieve optimal therapeutic outcomes.
• If symptoms persist or worsen after 48 hours of treatment, medical advice should be sought.

Dosage:

• For adults and children over 12 years of age: The initial dosage is 4mg (two tablets) followed by 2mg (one tablet) after each loose stool, not exceeding a maximum daily dose of 8mg (four tablets).
• For children aged 6 to 12 years: The recommended initial dosage is 2mg (one tablet) followed by 1mg (half a tablet) after each loose stool, with a maximum daily dose of 6mg (three tablets).

Pharmacokinetics:

• Loperamide is well absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 2 to 5 hours following oral administration.
• It undergoes extensive first-pass metabolism in the liver, primarily via cytochrome P450 enzymes, leading to the formation of its active metabolite, desmethyl loperamide.
• Loperamide and its metabolites are excreted mainly in the feces, with minimal renal elimination.

Pharmacodynamics:

• Loperamide exerts its pharmacological effects by binding to opioid receptors in the intestinal wall, inhibiting acetylcholine release and reducing peristalsis.
• By slowing gut motility and increasing transit time, loperamide promotes water and electrolyte absorption, resulting in the formation of firmer stools and decreased frequency of bowel movements.

Side Effects:

• Common side effects of Loperamide HCl Tablets may include constipation, abdominal discomfort, nausea, and dizziness.
• Rarely, individuals may experience allergic reactions, including rash, itching, and swelling of the face or throat.
• It is important to monitor for signs of dehydration or electrolyte imbalance, especially in patients with severe diarrhea or underlying medical conditions.

Trust in the efficacy and reliability of Loperamide HCl Tablets from AIT Pharmaceuticals Division. We are committed to providing quality gastrointestinal care and helping individuals manage symptoms of diarrhea effectively. For more information, please visit our website or consult your healthcare provider.