Drug Classification:

Lornoxicam belongs to the class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic properties by inhibiting the synthesis of prostaglandins, which are mediators of pain and inflammation.

Formulations:

• Lornoxicam Tablets:
  • Strength: Available in 4mg and 8mg tablets
  • Product Form: Oral tablets for easy administration
  • Packing Specifications: Each pack contains 20 tablets

Indications:

Lornoxicam is indicated for the treatment of various painful and inflammatory conditions, including:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute gout
• Postoperative pain
• Dysmenorrhea
• Dental pain

Usage:

• Lornoxicam tablets should be taken orally with a full glass of water, preferably with or after food to minimize gastrointestinal irritation.
• The duration of treatment and dosage regimen may vary depending on the specific condition being treated, the patient’s response to therapy, and other individual factors.

Dosage:

• The recommended dosage of Lornoxicam may vary depending on the severity of the pain or inflammation and the patient’s medical history.
• For adults, the usual starting dose is 4mg or 8mg once daily. The maximum daily dose should not exceed 16mg.
• Dosage adjustments may be necessary in elderly patients and those with renal or hepatic impairment.

Pharmacokinetics:

• Absorption: Lornoxicam is rapidly and extensively absorbed after oral administration, with peak plasma concentrations achieved within 2 hours.
• Distribution: The drug is highly protein-bound (more than 99%) and is distributed widely throughout the body, including synovial fluid.
• Metabolism: Lornoxicam undergoes hepatic metabolism via cytochrome P450 enzymes, primarily CYP2C9 and CYP3A4.
• Elimination: The elimination half-life of Lornoxicam is approximately 3-5 hours. It is primarily excreted in the urine as metabolites.

Pharmacodynamics:

• Lornoxicam exerts its pharmacological effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the production of prostaglandins involved in pain and inflammation.

Side Effects:

• Common side effects of Lornoxicam may include:
  • Gastrointestinal disturbances (e.g., dyspepsia, abdominal pain)
  • Headache
  • Dizziness
  • Skin rash
  • Elevated liver enzymes
• Serious adverse reactions such as gastrointestinal bleeding, ulceration, and perforation may occur, particularly with long-term use or high doses.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Lornoxicam Range in the management of pain and inflammation. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.