Drug Classification:

Losartan Potassium belongs to the class of medications known as angiotensin II receptor blockers (ARBs). It works by blocking the action of angiotensin II, a hormone that constricts blood vessels, thereby promoting vasodilation and lowering blood pressure.

Formulations:

• Losartan Potassium Tablets:
  • Strength: Available in 25mg and 50mg strengths.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each.

Indications:

Losartan Potassium Tablets are indicated for:

• Treatment of hypertension (high blood pressure) in adults and pediatric patients aged 6 years and older to lower blood pressure.
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy.
• Management of diabetic nephropathy in patients with type 2 diabetes and hypertension.

Usage:

• Losartan Potassium Tablets should be taken orally once daily with or without food, as directed by a healthcare professional.
• It is essential to adhere to the prescribed dosage and administration regimen to achieve optimal therapeutic outcomes.

Dosage:

• The recommended starting dose of Losartan Potassium Tablets for most adults with hypertension is 50mg once daily.
• The dosage may be adjusted based on individual patient response and tolerability, with a maximum dose of 100mg once daily.
• Pediatric dosing should be determined based on the child’s body weight and individual requirements.

Pharmacokinetics:

• Losartan is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. It undergoes hepatic metabolism to form its active metabolite, losartan carboxylic acid.
• The active metabolite of losartan exhibits a prolonged half-life, allowing for once-daily dosing and sustained antihypertensive effects.

Pharmacodynamics:

• Losartan Potassium exerts its antihypertensive effects by selectively blocking the angiotensin II receptor subtype AT1, thereby preventing angiotensin II-mediated vasoconstriction and aldosterone secretion.
• By inhibiting the renin-angiotensin-aldosterone system (RAAS), Losartan Potassium promotes vasodilation, reduces blood pressure, and protects against target organ damage.

Side Effects:

• Common side effects associated with Losartan Potassium Tablets may include dizziness, headache, fatigue, and upper respiratory tract infections.
• Rare but serious adverse effects such as hyperkalemia (elevated potassium levels), hypotension, and renal impairment may occur and require medical attention.
• Patients should be monitored regularly for signs of electrolyte imbalance, renal function, and blood pressure control during treatment with Losartan Potassium.

Experience the proven efficacy and safety of AIT Pharmaceuticals Division’s Losartan Potassium Tablets in the management of hypertension and cardiovascular risk reduction. For more information, please contact us. Your heart health is our priority, and we are dedicated to supporting your well-being.