Description

Drug Classification:

Metoclopramide belongs to the class of medications known as prokinetic agents. It exerts its effects by stimulating the motility of the upper gastrointestinal tract and by blocking dopamine receptors in the chemoreceptor trigger zone, thereby relieving symptoms associated with gastrointestinal dysfunction.

Formulations:

• Metoclopramide Liquid Ampule:
  • Strength: 10mg
  • Product Form: Liquid ampule for oral or intravenous administration
  • Packing Specifications: Available in packs of 10 ampules

Indications:

Metoclopramide is indicated for the treatment of various gastrointestinal disorders, including:

• Gastroesophageal reflux disease (GERD)
• Gastroparesis
• Nausea and vomiting associated with chemotherapy or surgery
• Diabetic gastroparesis
• Refractory gastroesophageal reflux

Usage:

• Metoclopramide should be taken orally or administered intravenously as directed by a healthcare professional.
• It can be taken with or without food.
• The duration of treatment may vary depending on the specific condition being treated and the individual patient’s response to therapy.

Dosage:

• The recommended dosage of Metoclopramide may vary depending on the indication being treated.
• For the treatment of GERD and gastroparesis, the usual adult dosage is 10-15mg orally 30 minutes before meals and at bedtime.
• For the prevention of chemotherapy-induced nausea and vomiting, the usual adult dosage is 1-2mg/kg administered intravenously over 15-30 minutes prior to chemotherapy.

Pharmacokinetics:

• Absorption: Metoclopramide is rapidly and well absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours.
• Distribution: The drug is widely distributed throughout the body, including the central nervous system.
• Metabolism: Metoclopramide undergoes hepatic metabolism, primarily by the cytochrome P450 enzyme system.
• Elimination: The elimination half-life of Metoclopramide is approximately 2-6 hours, with the majority of the drug excreted unchanged in the urine.

Pharmacodynamics:

• Metoclopramide exerts its pharmacological effects by enhancing gastrointestinal motility and accelerating gastric emptying. It also possesses antiemetic properties due to its antagonism of dopamine receptors in the chemoreceptor trigger zone.

Side Effects:

• Common side effects of Metoclopramide may include:
  • Drowsiness
  • Restlessness
  • Fatigue
  • Diarrhea
  • Extrapyramidal symptoms (e.g., dystonia, akathisia)
• Serious adverse reactions such as tardive dyskinesia and neuroleptic malignant syndrome are rare but may occur, particularly with long-term use or high doses.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Metoclopramide Range in the management of gastrointestinal disorders. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.