Description

Formulations:

• Naproxen Sodium Tablets:
  • Strength: Available in 250mg, 275mg, and 500mg formulations
  • Product Form: Oral tablets for easy administration
  • Packing Specifications: Each pack contains 20 tablets for your convenience

Indications:

Naproxen Sodium is indicated for the treatment of various inflammatory and painful conditions, including:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute gout
• Musculoskeletal disorders
• Dysmenorrhea
• Tendinitis
• Bursitis

Usage:

• Naproxen Sodium tablets are intended for oral administration.
• The dosage and duration of treatment should be individualized based on the severity of the condition and the patient’s response to therapy.
• It is recommended to take Naproxen Sodium with food or milk to minimize gastrointestinal side effects.

Dosage:

• The recommended dosage of Naproxen Sodium typically ranges from 250mg to 500mg twice daily.
• For mild to moderate pain or inflammation, a starting dose of 250mg to 375mg twice daily may be sufficient.
• Dosage adjustments may be necessary in elderly patients, patients with renal or hepatic impairment, and those at risk of gastrointestinal adverse effects.

Pharmacokinetics:

• Absorption: Naproxen Sodium is rapidly and completely absorbed following oral administration, with peak plasma concentrations achieved within 2 to 4 hours.
• Distribution: Naproxen Sodium is highly protein-bound and widely distributed throughout the body, including synovial fluid.
• Metabolism: Naproxen Sodium undergoes extensive hepatic metabolism, primarily via hydroxylation and conjugation, leading to the formation of inactive metabolites.
• Elimination: The elimination half-life of Naproxen Sodium is approximately 12 to 17 hours, with the majority of the drug excreted renally as metabolites.

Pharmacodynamics:

• Naproxen Sodium exerts its anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins involved in the inflammatory process.

Side Effects:

• Common side effects of Naproxen Sodium may include:
  • Gastrointestinal disturbances such as dyspepsia, abdominal pain, and gastritis
  • Renal impairment, including fluid retention and edema
  • Hematological effects such as anemia and thrombocytopenia
  • Skin reactions, including rash and photosensitivity
• Serious adverse reactions such as gastrointestinal bleeding, renal failure, and hypersensitivity reactions may occur, particularly with prolonged use or in patients with pre-existing conditions.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Naproxen Sodium Range for effective pain relief and inflammation management. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.