Drug Classification:

Nebivolol belongs to the class of medications known as beta-blockers. Specifically, it is a third-generation beta-blocker with unique vasodilatory properties. Nebivolol works by blocking beta-adrenergic receptors in the heart and blood vessels, leading to decreased heart rate and blood pressure. Additionally, it promotes vasodilation by stimulating the release of nitric oxide, resulting in improved blood flow and reduced cardiac workload.

Formulations:

• Nebivolol Tablets:
  • Strengths: Available in 5mg and 10mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 20 tablets each.

Indications:

Nebivolol Tablets are indicated for:

• Treatment of hypertension (high blood pressure) to lower blood pressure and reduce the risk of cardiovascular events such as heart attacks and strokes.
• Management of chronic heart failure in patients with reduced ejection fraction, in conjunction with standard heart failure therapies.

Usage:

• Nebivolol Tablets should be taken orally once daily with or without food, as directed by a healthcare professional.
• It is essential to adhere to the prescribed dosage and administration regimen to achieve optimal therapeutic outcomes.
• Patients should not abruptly discontinue Nebivolol therapy without consulting their healthcare provider, as sudden withdrawal may lead to worsening of cardiovascular conditions.

Dosage:

• The recommended starting dose of Nebivolol for hypertension is 5mg once daily, which may be increased to 10mg once daily based on individual patient response.
• For heart failure management, the initial dose of Nebivolol is typically 1.25mg once daily, with gradual uptitration to the target maintenance dose of 10mg once daily over several weeks.

Pharmacokinetics:

• Nebivolol is well absorbed after oral administration, with peak plasma concentrations reached within 1 to 4 hours. It undergoes extensive hepatic metabolism and has a half-life of approximately 10 hours.
• The drug is primarily excreted in the urine as metabolites.

Pharmacodynamics:

• Nebivolol exerts its therapeutic effects by selectively blocking beta-1 adrenergic receptors in the heart, resulting in decreased heart rate and contractility.
• Additionally, Nebivolol promotes vasodilation by stimulating the release of nitric oxide, leading to relaxation of blood vessels and reduced peripheral resistance, which contributes to its antihypertensive efficacy.

Side Effects:

• Common side effects associated with Nebivolol Tablets may include fatigue, dizziness, headache, and nausea.
• Less common but potentially serious adverse effects such as bradycardia (slow heart rate), hypotension, and exacerbation of heart failure may occur and require medical attention.
• Patients should be monitored regularly for heart rate, blood pressure, and signs of worsening heart failure during treatment with Nebivolol Tablets.

Experience the benefits of Nebivolol for effective management of hypertension and heart failure, exclusively from AIT Pharmaceuticals Division. For more information, please contact us. Your cardiovascular health is our priority, and we are dedicated to providing innovative solutions for better patient care.