Description

Pharmacokinetics:

Ondansetron, a selective serotonin 5-HT3 receptor antagonist, exerts its antiemetic effects by blocking serotonin both peripherally, on vagal nerve terminals, and centrally in the chemoreceptor trigger zone of the area postrema. It is rapidly absorbed following oral administration, with peak plasma concentrations achieved within 1 to 2 hours. The drug is extensively metabolized in the liver, primarily by hepatic cytochrome P450 enzymes, and eliminated predominantly via the kidneys.

Pharmacodynamics:

Ondansetron’s blockade of serotonin receptors inhibits the emetic response triggered by chemotherapy, radiation therapy, and postoperative procedures. By modulating neurotransmitter activity in the central and peripheral nervous systems, Ondansetron effectively suppresses nausea and vomiting, providing relief and improving quality of life for patients.

Drug Classification:

Ondansetron is classified as an antiemetic agent, specifically a selective serotonin 5-HT3 receptor antagonist.

Formulations:

• Ondansetron HCl 4mg tablets (10’s)
• Ondansetron HCl 8mg tablets (10’s)
• Ondansetron HCl 8mg tablets (5’s)
• Ondansetron HCl liquid ampoule 8mg/4ml (5’s)

Indications:

AIT’s Ondansetron HCl Range is indicated for the prevention and treatment of nausea and vomiting induced by chemotherapy, radiotherapy, and surgery. It is also effective in mitigating postoperative nausea and vomiting.

Usage:

For oral tablets, administer with or without food as directed by a healthcare professional. For liquid ampoules, administer via intravenous injection as prescribed by a physician.

Dosage:

The recommended dosage of Ondansetron HCl varies depending on the indication and patient factors. Consult a healthcare provider for personalized dosing instructions.

Side Effects:

Common side effects of Ondansetron HCl may include headache, constipation, diarrhea, dizziness, and fatigue. Rare but serious adverse effects such as allergic reactions and QT prolongation may occur. Promptly report any adverse reactions to a healthcare professional.

Packing Specs:

• Ondansetron HCl 4mg tablets: 10 tablets per pack
• Ondansetron HCl 8mg tablets (10’s): 10 tablets per pack
• Ondansetron HCl liquid ampoule 8mg/4ml: 5 ampoules per pack

Experience relief from nausea and vomiting with AIT Pharmaceuticals Division’s Ondansetron HCl Range. Trust in our commitment to quality and efficacy for superior gastrointestinal symptom management.