Description

Formulations:

• Orphenadrine Citrate Paracetamol Tablets:
  • Strength: Each tablet contains Orphenadrine Citrate 35mg and Paracetamol 450mg
  • Product Form: Oral tablets for easy administration
  • Packing Specifications: Available in packs of 30 tablets for your convenience

Indications:

Orphenadrine Citrate Paracetamol tablets are indicated for the management of musculoskeletal conditions associated with:

• Muscle spasms
• Strains and sprains
• Rheumatic disorders
• Back pain
• Postoperative pain

Usage:

• Orphenadrine Citrate Paracetamol tablets are intended for oral administration.
• The medication should be taken with a full glass of water, with or without food.
• It is essential to follow the prescribed dosage and duration of treatment as directed by your healthcare provider.

Dosage:

• The recommended dosage of Orphenadrine Citrate Paracetamol tablets may vary depending on the severity of the condition and individual patient response.
• The usual dosage for adults is one tablet taken orally every 8 to 12 hours, as needed for pain relief.
• The maximum daily dose should not exceed 3 tablets in 24 hours to avoid adverse effects.

Pharmacokinetics:

• Absorption: Orphenadrine Citrate and Paracetamol are well absorbed following oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• Distribution: Both drugs are distributed widely throughout the body, with Orphenadrine Citrate crossing the blood-brain barrier.
• Metabolism: Orphenadrine Citrate undergoes extensive hepatic metabolism, while Paracetamol is metabolized primarily in the liver by glucuronidation and sulfation.
• Elimination: The elimination half-life of Orphenadrine Citrate is approximately 13 to 14 hours, while Paracetamol has a half-life of about 2 to 3 hours. Both drugs are excreted primarily in the urine.

Pharmacodynamics:

• Orphenadrine Citrate exerts its muscle relaxant effects by inhibiting central nervous system activity, particularly within the brainstem.
• Paracetamol acts centrally to inhibit prostaglandin synthesis in the central nervous system, thereby reducing pain and fever.

Side Effects:

• Common side effects of Orphenadrine Citrate Paracetamol tablets may include:
  • Drowsiness, dizziness, and blurred vision
  • Dry mouth, constipation, and urinary retention
  • Nausea, vomiting, and gastrointestinal disturbances
• Serious adverse reactions such as allergic reactions, hepatotoxicity, and cardiovascular events may occur, although they are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Orphenadrine Citrate Paracetamol Range for effective pain relief and muscle relaxation. For more information, please contact us. We are committed to providing superior pharmaceutical solutions to healthcare professionals worldwide.