Description

Drug Classification:

Paliperidone belongs to the class of drugs known as atypical antipsychotics. It acts primarily as a dopamine D2 and serotonin 5-HT2 receptor antagonist, exerting its therapeutic effects by modulating neurotransmitter activity in the brain to alleviate symptoms of psychosis.

Formulations:

• Paliperidone Tablets:
  • Strength: Available in 3mg and 6mg tablets.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 29 tablets.

Indications:

Paliperidone Tablets are indicated for the following conditions:

• Schizophrenia: Paliperidone is indicated for the treatment of schizophrenia, including both acute exacerbations and maintenance therapy to prevent relapse.
• Related Psychotic Disorders: Paliperidone may also be used in the treatment of schizoaffective disorder and other psychotic disorders characterized by delusions, hallucinations, disorganized thinking, and other positive and negative symptoms.

Usage:

• Paliperidone Tablets should be taken orally with water, preferably with food to minimize gastrointestinal discomfort.
• The dosage and dosing schedule should be individualized based on the patient’s clinical response and tolerability.
• It is important to adhere to the prescribed dosage and follow-up appointments with a healthcare professional for optimal management of symptoms.

Dosage:

• The recommended starting dose of Paliperidone for the treatment of schizophrenia in adults is 6 mg once daily.
• For some patients, a lower starting dose of 3mg once daily may be appropriate, with gradual titration based on individual response and tolerability.
• Maintenance therapy typically involves doses ranging from 3mg to 12 mg once daily, depending on the patient’s clinical status and previous treatment history.

Pharmacokinetics:

• Paliperidone is the active metabolite of risperidone and is formed via hydrolysis of the parent compound.
• Following oral administration, Paliperidone is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 4 to 8 hours.
• The drug is extensively metabolized in the liver, primarily via oxidative pathways, with minimal renal elimination.
• Paliperidone has a half-life of approximately 23 hours, allowing for once-daily dosing.

Pharmacodynamics:

• As an atypical antipsychotic, Paliperidone exerts its therapeutic effects by blocking dopamine D2 and serotonin 5-HT2 receptors in the brain.
• By antagonizing these receptors, Paliperidone helps to normalize neurotransmitter signaling pathways, thereby reducing the severity of psychotic symptoms associated with schizophrenia and related disorders.

Side Effects:

• Common side effects associated with Paliperidone may include somnolence, extrapyramidal symptoms (such as tremor, rigidity, and dystonia), weight gain, and metabolic abnormalities.
• Less common but potentially serious side effects may include orthostatic hypotension, QT prolongation, and neuroleptic malignant syndrome.
• Patients should be monitored for signs of adverse reactions, and therapy should be adjusted or discontinued as necessary.

Trust in the efficacy and safety of Paliperidone Tablets from AIT Pharmaceuticals Division. Whether you are managing schizophrenia or related psychotic disorders, our product offers a reliable solution to help you achieve symptom control and improve your quality of life. For more information, please visit our website or consult your healthcare provider.