Description

Drug Classification:

Paroxetine as HCl belongs to the class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is primarily used as an antidepressant to treat major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD).

Formulations:

• Paroxetine Hydrochloride Tablets:
  • Strength: Available in 20mg formulation.
  • Product Form: Oral tablets for easy administration.
  • Packing Specifications: Packaged in blister packs containing 10 tablets for convenient dosing.

Indications:

Paroxetine Hydrochloride Tablets are indicated for the following conditions:

• Major Depressive Disorder (MDD): Treatment of MDD, characterized by persistent feelings of sadness and loss of interest or pleasure in activities.
• Obsessive-Compulsive Disorder (OCD): Management of OCD, a mental health disorder characterized by obsessions and compulsions.
• Panic Disorder: Treatment of panic disorder, marked by recurrent panic attacks and associated symptoms.
• Social Anxiety Disorder: Management of social anxiety disorder, characterized by excessive fear of social situations.
• Generalized Anxiety Disorder (GAD): Treatment of GAD, a condition marked by excessive worry or anxiety about various aspects of life.
• Post-Traumatic Stress Disorder (PTSD): Management of PTSD, a mental health condition triggered by a traumatic event.

Usage:

• Paroxetine Hydrochloride Tablets should be taken orally, with or without food.
• It is essential to adhere to the prescribed dosage and duration of treatment as directed by your healthcare provider.
• Do not abruptly stop taking paroxetine without consulting your healthcare provider, as discontinuation symptoms may occur.

Dosage:

• The recommended starting dose of paroxetine for adults is usually 20mg once daily, with adjustments made by the healthcare provider based on individual response and tolerability.
• The dosage may be increased gradually, up to a maximum of 50mg per day for the treatment of certain conditions.
• For elderly patients or those with hepatic impairment, lower starting doses may be recommended.

Pharmacokinetics:

• Paroxetine is well absorbed after oral administration, with peak plasma concentrations achieved within 4 to 6 hours.
• It undergoes extensive hepatic metabolism via the cytochrome P450 system, primarily CYP2D6 and CYP3A4.
• The elimination half-life of paroxetine is approximately 21 hours, allowing for once-daily dosing.

Pharmacodynamics:

• As an SSRI, paroxetine works by selectively inhibiting the reuptake of serotonin (5-HT) at the synaptic cleft, thereby increasing the concentration of serotonin in the brain.
• By enhancing serotonin neurotransmission, paroxetine helps alleviate symptoms of depression, anxiety, and other related disorders.

Side Effects:

• Common side effects of Paroxetine Hydrochloride Tablets may include nausea, dry mouth, headache, drowsiness, insomnia, and sexual dysfunction.
• Some individuals may experience gastrointestinal disturbances, such as diarrhea or constipation, as well as weight changes.
• Rare but serious side effects may include serotonin syndrome, suicidal ideation, and hyponatremia.
• It is essential to report any unusual symptoms or adverse reactions to your healthcare provider promptly.

Trust in the efficacy and safety of Paroxetine Hydrochloride Tablets from AIT Pharmaceuticals Division. We are dedicated to meeting the healthcare needs of our patients and ensuring their well-being. For more information, please visit our website or consult your healthcare provider.