Drug Classification:

Pioglitazone belongs to the thiazolidinedione class of antidiabetic medications. It works by improving insulin sensitivity in muscle and adipose tissue, thereby enhancing glucose uptake and utilization, leading to better glycemic control.

Formulations:

• Pioglitazone Tablets:
  • Strength: Each tablet contains Pioglitazone Hydrochloride equivalent to 30mg of Pioglitazone.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specifications: Packaged in blister packs containing 14 tablets each, ensuring ease of use and portability.

Indications:

Pioglitazone Tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It can be used as monotherapy or in combination with other antidiabetic medications, such as metformin, sulfonylureas, or insulin.

Usage:

• Pioglitazone Tablets should be taken orally once daily, with or without food.
• It is important to adhere to the prescribed dosage and regimen recommended by your healthcare provider.
• Regular monitoring of blood glucose levels and liver function is essential during treatment with Pioglitazone.

Dosage:

• The recommended dosage of Pioglitazone Tablets is 30 mg once daily.
• Dose adjustment may be necessary based on individual patient factors such as glycemic response and tolerability.
• Pioglitazone can be used alone or in combination with other antidiabetic medications to achieve optimal glycemic control.

Pharmacokinetics:

• Pioglitazone is rapidly absorbed after oral administration, with peak plasma concentrations achieved within 2 hours.
• It is extensively metabolized in the liver via cytochrome P450 enzymes, primarily CYP2C8 and CYP3A4.
• The elimination half-life of Pioglitazone is approximately 3 to 7 hours.

Pharmacodynamics:

• Pioglitazone exerts its pharmacological effects by activating peroxisome proliferator-activated receptor gamma (PPAR-γ) receptors, which regulate gene expression involved in glucose and lipid metabolism.
• This mechanism of action results in improved insulin sensitivity, decreased hepatic glucose production, and enhanced peripheral glucose uptake.

Side Effects:

• Common side effects of Pioglitazone Tablets may include weight gain, edema (fluid retention), and mild hypoglycemia when used in combination with insulin or sulfonylureas.
• Other potential side effects may include upper respiratory tract infection, headache, and muscle pain.
• Contact your healthcare provider if you experience any persistent or severe side effects while taking Pioglitazone Tablets.

Experience the benefits of Pioglitazone Tablets from AIT Pharmaceuticals Division. Trust in our commitment to providing high-quality medications to support the management of type 2 diabetes mellitus and improve overall health outcomes. For more information, please visit our website or consult your healthcare provider.