Description

Drug Classification:

Pregabalin Tablets belong to the class of drugs known as anticonvulsants or antiepileptic drugs (AEDs). Originally developed to treat epilepsy, Pregabalin is also effective in managing neuropathic pain, anxiety disorders, and certain types of seizures.

Formulations:

• Pregabalin Tablets:
  • Strengths: Available in 25mg, 50mg, 75mg, 100mg, 150mg, and 300mg formulations.
  • Product Form: Oral tablets for convenient administration.
  • Packing Specs: Each pack contains 14 tablets.

Indications:

Pregabalin Tablets are indicated for the treatment of the following conditions:

• Epilepsy: Pregabalin is effective as adjunctive therapy in the treatment of partial-onset seizures in adults.
• Neuropathic Pain: This medication is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, and spinal cord injury.
• Fibromyalgia: Pregabalin is approved for the treatment of fibromyalgia, providing relief from pain and improving sleep quality.
• Generalized Anxiety Disorder (GAD): Pregabalin is also indicated for the management of GAD in adults.

Usage:

• Pregabalin Tablets should be taken orally with water, with or without food.
• It is important to follow the prescribed dosage and dosing schedule as directed by a healthcare professional.
• Tablets should be swallowed whole and not crushed, chewed, or opened, as this may affect the release of the medication.

Dosage:

• The recommended starting dose of Pregabalin for epilepsy is typically 75mg to 150mg per day, divided into two or three doses.
• For neuropathic pain and fibromyalgia, the starting dose is usually 75mg twice daily or 50mg three times daily.
• Dosage adjustments may be made based on individual response and tolerability, with a maximum recommended dose of 600mg per day.

Pharmacokinetics:

• Pregabalin is rapidly absorbed in the small intestine, with peak plasma concentrations achieved within 1 to 3 hours after administration.
• It undergoes negligible metabolism and is primarily eliminated unchanged in the urine.
• The elimination half-life of Pregabalin is approximately 6 hours.

Pharmacodynamics:

• Pregabalin exerts its antiepileptic and analgesic effects by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system.
• This mechanism of action reduces the release of excitatory neurotransmitters, such as glutamate, and inhibits neuronal hyperexcitability, thereby suppressing seizures and modulating pain transmission.

Side Effects:

• Common side effects associated with Pregabalin Tablets may include dizziness, somnolence, peripheral edema, dry mouth, and weight gain.
• Less common but potentially serious side effects may include respiratory depression, suicidal ideation, and hypersensitivity reactions.
• Patients should be advised to report any new or worsening symptoms to their healthcare provider promptly.

Trust in the efficacy and safety of Pregabalin Tablets from AIT Pharmaceuticals Division. Whether you are managing epilepsy, neuropathic pain, fibromyalgia, or anxiety disorders, our product offers a reliable solution to help you achieve symptom control and improve your quality of life. For more information, please visit our website or consult your healthcare provider.