Formulations:

• Cefoperazone + Sulbactam Vial: Available in strengths of 1gm and 2gm, our vials contain a sterile powder for reconstitution, providing flexibility in dosage administration.

Indications:

• Our Cefoperazone + Sulbactam Vial is indicated for the treatment of:
  • Severe intra-abdominal infections
  • Respiratory tract infections, including pneumonia and bronchitis
  • Urinary tract infections
  • Skin and soft tissue infections
  • Septicemia and meningitis caused by susceptible organisms

Pharmacokinetics:

• Absorption: Cefoperazone and sulbactam are administered parenterally and are rapidly absorbed after intravenous injection.
• Distribution: Both drugs achieve high concentrations in various body tissues and fluids, including the lungs, kidneys, and cerebrospinal fluid.
• Metabolism: Cefoperazone undergoes minimal metabolism in the liver, while sulbactam is primarily excreted unchanged in the urine.
• Elimination: The elimination half-life of cefoperazone is approximately 1-2 hours, while sulbactam has a shorter half-life of about 0.5-1 hour.

Pharmacodynamics:

• Cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death.
• Sulbactam acts as a beta-lactamase inhibitor, preventing the inactivation of cefoperazone by bacterial beta-lactamases and enhancing its antibacterial activity against beta-lactamase-producing strains.

Usage:

• Our Cefoperazone + Sulbactam Vial is intended for intravenous administration by healthcare professionals trained in the proper handling and reconstitution of injectable medications.

Dosage:

• The recommended dosage of Cefoperazone + Sulbactam varies depending on the type and severity of the infection, as well as the patient’s age, weight, and renal function.
• Dosage adjustments may be necessary in patients with impaired renal function to prevent drug accumulation and toxicity.

Side Effects:

• Common side effects of Cefoperazone + Sulbactam may include:
  • Nausea
  • Diarrhea
  • Injection site reactions
  • Hypersensitivity reactions, including rash and itching
• Serious side effects such as anaphylaxis and pseudomembranous colitis may occur, although they are rare.

Experience the effectiveness and reliability of AIT Pharmaceuticals Division’s Cefoperazone + Sulbactam Vial Range in the treatment of severe bacterial infections. For more information, please contact us.