Description

Formulations:

• Cefuroxime Tablets:

• • • Strengths: 250mg, 500mg, 750mg, and 1000mg
    • Product Form: Oral tablets for convenient administration
    • Packing Specs: Available in Tablets of 14’s

• Cefuroxime Vials:

• • Strengths: 250mg, 500mg, 750mg, and 1000mg
  • Product Form: Lyophilized powder for reconstitution for intravenous administration
  • Packing Specs: Available in vial packs of 1’s

Indications:

• Cefuroxime is indicated for the treatment of various bacterial infections caused by susceptible organisms, including:
  • Respiratory tract infections, such as bronchitis, pneumonia, and sinusitis
  • Urinary tract infections, including cystitis and pyelonephritis
  • Skin and soft tissue infections, including cellulitis and wound infections
  • Otitis media
  • Lyme disease
  • Septicemia and meningitis (in higher doses)

Pharmacokinetics:

• Absorption: Cefuroxime is well absorbed orally, with peak plasma concentrations reached within 2-3 hours after administration.
• Distribution: The drug is distributed widely into various body tissues and fluids, including the respiratory tract, urinary tract, and skin.
• Metabolism: Cefuroxime undergoes minimal metabolism in the liver, with the majority of the drug excreted unchanged in the urine.
• Elimination: The elimination half-life of cefuroxime is approximately 1-1.5 hours in adults with normal renal function.

Pharmacodynamics:

• Cefuroxime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell death.

Usage:

• Cefuroxime tablets are administered orally, while the vial formulation is for intravenous use.
• Healthcare professionals should reconstitute the dry vial as per the instructions provided before administration.

Dosage:

• The dosage of Cefuroxime varies depending on the type and severity of the infection, as well as the patient’s age, weight, and renal function.
• Dosage adjustments may be necessary in patients with impaired renal function to prevent drug accumulation and toxicity.

Side Effects:

• Common side effects of Cefuroxime may include:
  • Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea
  • Skin rash and allergic reactions
  • Superinfections, including fungal infections
• Serious side effects such as anaphylaxis and pseudomembranous colitis may occur, although they are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Cefuroxime Range in the management of bacterial infections. For more information, please contact us.