Description

Formulations:

• Cephradine Tablets:

• • • Strengths: 125mg DS and 250mg DS
    • Product Form: Dispersible tablets for oral administration
    • Packing Specs: Available in DS 60ml packs

• Cephradine Capsules:

• • • Strengths: 250mg and 500mg
    • Product Form: Capsules for oral administration
    • Packing Specs: Available in packs of 12’s

• Cephradine Dry Vial:

• • Strengths: 500mg and 1000mg
  • Product Form: Lyophilized powder for reconstitution for intravenous administration
  • Packing Specs: Available in single vial packs

Indications:

• Cephradine is indicated for the treatment of various bacterial infections caused by susceptible organisms, including:
  • Respiratory tract infections, such as pharyngitis, tonsillitis, bronchitis, and pneumonia
  • Urinary tract infections, including cystitis and pyelonephritis
  • Skin and soft tissue infections, including cellulitis, wound infections, and impetigo
  • Otitis media
  • Surgical prophylaxis

Usage:

• Cephradine tablets and capsules are intended for oral administration, while the dry vial formulation is for intravenous use.
• Healthcare professionals should reconstitute the dry vial as per the instructions provided before administration.

Dosage:

• The dosage of Cephradine varies depending on the type and severity of the infection, as well as the patient’s age, weight, and renal function.
• Dosage adjustments may be necessary in patients with impaired renal function to prevent drug accumulation and toxicity.

Pharmacokinetics:

• Absorption: Cephradine is well absorbed orally, with peak plasma concentrations reached within 1-2 hours after administration.
• Distribution: The drug is distributed widely into various body tissues and fluids, including the respiratory tract, urinary tract, and skin.
• Metabolism: Cephradine undergoes minimal metabolism in the liver, with the majority of the drug excreted unchanged in the urine.
• Elimination: The elimination half-life of cephradine is approximately 1-2 hours in adults with normal renal function.

Pharmacodynamics:

• Cephradine exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell death.

Side Effects:

• Common side effects of Cephradine may include:
  • Gastrointestinal disturbances, such as nausea, vomiting, and diarrhea
  • Skin rash and allergic reactions
  • Superinfections, including fungal infections
• Serious side effects such as anaphylaxis and pseudomembranous colitis may occur, although they are rare.

Experience the efficacy and reliability of AIT Pharmaceuticals Division’s Cephradine Range in the management of bacterial infections. For more information, please contact us.