Description

Drug Classification:

Quetiapine belongs to the class of medications known as atypical antipsychotics. It is used to treat schizophrenia, bipolar disorder, and major depressive disorder.

Formulations:

• Quetiapine Fumarate Tablets:
  • Strength: Available in 25mg tablets (packed in 30’s) and 100mg tablets (packed in 30’s).
  • Product Form: Oral tablets for convenient administration.

Indications:

Quetiapine Fumarate Tablets are indicated for the following conditions:

• Schizophrenia: Treatment of schizophrenia, a chronic and severe mental disorder characterized by hallucinations, delusions, and impaired cognitive function.
• Bipolar Disorder: Management of manic episodes associated with bipolar I disorder, as monotherapy or adjunctive therapy with lithium or divalproex.
• Major Depressive Disorder (MDD): Adjunctive treatment of MDD in adult patients who have not responded adequately to antidepressant therapy alone.

Usage:

• Quetiapine Fumarate Tablets should be taken orally, once or twice daily, with or without food, as directed by your healthcare provider.
• Dosage adjustments may be necessary based on individual response and tolerability.
• It is essential to follow the prescribed treatment regimen and consult your healthcare provider for any dose adjustments or changes.

Dosage:

• The recommended starting dose for schizophrenia is 25 mg twice daily, with gradual titration based on clinical response and tolerability, up to a maximum dose of 800mg per day.
• For bipolar disorder, the recommended starting dose is 50 mg twice daily, with subsequent dose adjustments as needed, up to a maximum of 800mg per day.
• In adjunctive treatment of MDD, the recommended starting dose is 50 mg once daily, with gradual titration up to a maximum dose of 300mg per day.

Pharmacokinetics:

• Quetiapine is well absorbed after oral administration, with peak plasma concentrations achieved within 1 to 2 hours.
• It undergoes extensive hepatic metabolism via cytochrome P450 enzymes, primarily CYP3A4 and CYP2D6.
• The elimination half-life of quetiapine is approximately 6 to 7 hours, allowing for twice-daily dosing in most patients.

Pharmacodynamics:

• Quetiapine exerts its therapeutic effects through antagonism of dopamine D2 and serotonin 5-HT2A receptors in the central nervous system, resulting in a reduction of psychotic symptoms and mood stabilization.

Side Effects:

• Common side effects of Quetiapine Fumarate Tablets may include drowsiness, dizziness, dry mouth, constipation, and weight gain.
• Some individuals may experience orthostatic hypotension, tachycardia, blurred vision, or metabolic changes such as increased blood sugar or lipid levels.
• Rare but serious side effects may include neuroleptic malignant syndrome, tardive dyskinesia, or agranulocytosis.
• It is important to report any unusual symptoms or adverse reactions to your healthcare provider promptly.

Trust in the efficacy and safety of Quetiapine Fumarate Tablets from AIT Pharmaceuticals Division. We are dedicated to providing innovative solutions for mental health disorders to enhance the lives of our patients. For more information, please visit our website or consult your healthcare provider.