Drug Classification:

Ranitidine belongs to the class of medications known as H2 receptor antagonists. It works by blocking the action of histamine on stomach cells, thereby reducing the production of stomach acid.

Formulations:

• Ranitidine Liquid Ampule:
  • Strength: 50mg
  • Product Form: Liquid ampule for oral administration
  • Packing Specifications: Available in packs of 10 ampules

Indications:

Ranitidine is indicated for the treatment and prevention of various gastrointestinal conditions, including:

• Peptic ulcer disease
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome
• Erosive esophagitis
• Heartburn and acid indigestion

Usage:

• Ranitidine should be taken orally as directed by a healthcare professional.
• It can be taken with or without food.
• The duration of treatment may vary depending on the specific condition being treated and the individual patient’s response to therapy.

Dosage:

• The recommended dosage of Ranitidine may vary depending on the indication being treated.
• For the treatment of peptic ulcer disease and GERD, the usual adult dosage is 150 mg twice daily or 300 mg once daily at bedtime.
• For the prevention of peptic ulcers, the usual adult dosage is 150 mg once daily at bedtime.
• Dosage adjustments may be necessary for patients with renal impairment.

Pharmacokinetics:

• Absorption: Ranitidine is well absorbed after oral administration, with peak plasma concentrations achieved within 1-3 hours.
• Distribution: The drug is widely distributed throughout the body, including the gastrointestinal tract.
• Metabolism: Ranitidine undergoes extensive hepatic metabolism, primarily by the cytochrome P450 enzyme system.
• Elimination: The elimination half-life of Ranitidine is approximately 2-3 hours, with the majority of the drug excreted unchanged in the urine.

Pharmacodynamics:

• Ranitidine exerts its pharmacological effects by competitively inhibiting the action of histamine at H2 receptors on the gastric parietal cells. This results in a reduction in gastric acid secretion and an increase in gastric pH, which helps alleviate symptoms associated with gastrointestinal disorders.

Side Effects:

• Common side effects of Ranitidine may include:
  • Headache
  • Dizziness
  • Nausea
  • Diarrhea
  • Constipation
• Serious adverse reactions are rare but may include allergic reactions, liver dysfunction, and hematologic abnormalities.

Experience the efficacy and safety of AIT Pharmaceuticals Division’s Ranitidine Range in the management of gastrointestinal disorders. For more information, please contact us. We are committed to providing high-quality pharmaceutical products to healthcare professionals worldwide.